MINE与ICE方案治疗复发难治性淋巴瘤的疗效比较  

Clinical Comparative Study of the Effect of MINE and ICE Regimen on Relapsed and Refractory Lymphoma

作　　者：郝杰 李雪莲 李良群 关爽 王黎[2] 

机构地区：[1]上海市闸北区北站医院肿瘤科,200070 [2]上海交通大学医学院附属瑞金医院,200025

出　　处：《实用癌症杂志》2012年第1期61-63,共3页The Practical Journal of Cancer

摘　　要：目的比较分析MINE与ICE方案治疗复发难治性淋巴瘤的临床疗效及安全性。方法对56例复发难治性非霍奇金淋巴瘤(NHL)患者,分别采用MINE与ICE 2种不同的方案化疗,每组各28例。比较2组患者的近期疗效、生活质量状况及不良反应。结果 MINE组和ICE组的有效率分别为60.7%和67.9%,差异无统计学意义(P>0.05);MINE组Karnofsky评分改善情况显著优于ICE组,差异均有统计学意义;2组骨髓抑制与脱发无显著性差异,而MINE组的胃肠道反应较ICE组轻,差异有统计学意义(P<0.05)。结论 MINE与ICE 2种化疗方案的近期疗效相当,但MINE在改善患者生活质量及减轻消化道副反应方面有一定的优势,可作为一线方案耐药后的首选补救方案。Objective To compare the effect and safety of MINE and ICE Regimen in the treatment of relapsed and refractory lymphoma.Methods 56 patients with relapsed or refractory non-Hodgkin＇s lymphoma（NHL）were treated by MINE（n=28） or ICE（n=28） Regimen.Short-term effect,quality of life and main toxicities were compared and analyzed after chemotherapy treatments.Results The effective rate for the two group were 60.7% and 67.9%,respectively（P0.05）.After chemotherapy treatment,the score of Karnofsky in MINE group improved more remarkedly than those in ICE group（P0.05）.There was no significant difference on the main toxicities of myelosuppression and alopecia between MINE and ICE group（P0.05）,while the gastrointestinal symptoms in MINE group was significantly lower than that in ICE group（P0.05）.Conclusion MINE and ICE Regimen have similar effect for NHL.MINE Regimen has certain superiority on the improvement of quality of life and reduction of gastrointestinal symptoms,so it can be used as a first remedial program after first-line drug resistance.

关 键 词：非霍奇金淋巴瘤 MINE方案 ICE方案 

分 类 号：R733.1[医药卫生—肿瘤]