3509例宫颈活检临床病理分析  

Clinical pathological analysis of 3 509 cases with cervical biopsy

作　　者：张庆华[1] 沈健[1] 袁静萍[1] 胡婷[2] 杨茹[2] 李雄[2] 黄科程[2] 贾瑶[2] 王少帅[2] 陈枝岚[2] 黄磊[1] 田训[1] 周航[2] 唐方徐[2] 李双[2] 

机构地区：[1]武汉市中心医院 [2]华中科技大学同济医学院附属同济医院肿瘤生物医学中心,湖北武汉430030

出　　处：《中国妇幼保健》2012年第5期726-728,共3页Maternal and Child Health Care of China

基　　金：国家自然科学基金资助项目〔81101964〕;国家重点基础发展计划(973)资助项目〔2002CB513100〕

摘　　要：目的:分析宫颈活检在宫颈病变检测中的临床应用价值。方法:回顾性分析2007年9月～2010年5月武汉市中心医院门诊就诊行宫颈活检患者3509例病理资料。结果:宫颈癌前病变417例(11.89%),宫颈癌83例(2.37%),癌前病变高发年龄为30～49岁,宫颈癌高发年龄为40～55岁。腺癌12例,占癌症比例14.46%;P16,Ki67染色阳性在正常或炎症宫颈组织、CINⅠ、CINⅡ、CINⅢ分别为25.00%、75.00%、100.00%、100.00%与32.00%、90.00%、100.00%、100.00%。结论:30～49岁年龄段是女性宫颈病变高发年龄段,免疫组化染色可以有效鉴别宫颈良性病变与癌前病变,应积极行宫颈活检明确宫颈病变诊断。Objective：To analyze the application value of cervix biopsy in clinic.Methods：The pathological data of 3 509 patients who had accepted cervix biopsy in The Central Hospital of Wuhan from September 2007 to May 2010 were collected and analyzed.Results：417（11.89%） cases of cervical precancerous lesion and 83（2.37%） cases of cervical cancer were detected.The age group of high incidence rate of precancerous lesion was 30-49 years old while that of cervical cancer was 40-55 years old.There were 12 cases of cervical adenocarcinoma and the proportion was 14.46%.The positive rates of P16 were 25.00%,75.00%,100.00% and 100.00% according to the histological results of normal,CINⅠ,CIN Ⅱand CINⅢ while the positive rates of Ki67 were 32.00%,90.00%,100.00% and 100.00%.Conclusion：The age group of high incidence rate of cervical lesion is 30-49 years old.Immunohistochemistry can effectively distinguish cervical benign lesion and cervical precancerous lesion.Cervical biopsy should be implemented actively to confirm cervical lesion.

关 键 词：宫颈病变 病理组织学 发病年龄 宫颈活检 

分 类 号：R737.33[医药卫生—肿瘤]