川芎提取工艺的研究  

Studies on Extraction Technology of Ferulic acid in Ligusticum chuanxiong Hort.

作　　者：马建春[1] 曾佳[1] 关石凤[1] 区通源[1] 

机构地区：[1]广东药学院附属第一医院药学部,广东广州510080

出　　处：《亚太传统医药》2012年第2期13-15,共3页Asia-Pacific Traditional Medicine

摘　　要：目的:优选川芎的提取方法和最佳工艺条件。方法:采用高效液相色谱法,以阿魏酸为检测指标,考察不同提取方法对其含量的影响;采用均匀试验设计进行提取工艺条件优选。结果:超临界CO2萃取法提取阿魏酸得率最高,最佳提取条件为:萃取压力45MPa,萃取温度55℃,解析压力6MPa,夹带剂为150%药材量的乙醇(mL.g-1),动态萃取3.5h。结论:优选工艺提取率高,合理,可行。Objective： To optimize the extraction technology of ferulic acid in Ligusticurn chuanxiong Hort. Methods： Using the content of ferulic acid as the index, to study the factors that affected the different extraction and optimize the best method of extrac- tion. Results：The method of Supercritical CO2 extraction （SFE） shares the highest extraction ratio and the best SFE conclusions were as follows： cosolvent was 150 % ethanol（mL ·g^-1）, extracting pressure was 45 MPa, extracting temperature was 55 ℃, pressure of resolution was 6 MPa, extracting time was 3.5h. Conclusion： The optimum extraction is reasonable and practicable , for it is has high extraction ratio.

关 键 词：川芎 阿魏酸 提取工艺 

分 类 号：R284.2[医药卫生—中药学]