COX-2及其抑制剂在大鼠痫性发作中的作用及其对大鼠认知功能的影响  

Roles of COX-2 and Its Inhibitors in Rats Epileptic Seizures and the Impact on Cognitive Function of Rats

作　　者：张佳[1] 和姬苓[1] 耿虹[2] 

机构地区：[1]包头医学院第一附属医院神经内二科,内蒙古包头014010 [2]包头医学院第一附属医院病理科,内蒙古包头014010

出　　处：《医学综述》2012年第3期357-358,370,共3页Medical Recapitulate

摘　　要：癫痫是反复发作的神经元异常放电所致的中枢神经系统功能失常疾病,其机制可能与脑内环氧化酶2(COX-2)的激活进而引起海马的病理变化有关。临床研究发现,痫性发作会对患者认知功能造成一定的损害。众多研究选择Wistar大鼠模拟颞叶癫痫模型来研究痫性发作的机制及其认知功能损害机制,COX-2抑制剂因其可能干预癫痫发作及预后而成为研究热点。现就COX-2及其抑制剂对癫痫发作及其对认知功能的影响进行综述。Epilepsy is a recurrent abnormal discharge of neurons in the central nervous system.Its pathogenesis may be related to activated brain cyclooxygenase-2（COX-2）caused hippocampal damage.Clinical studies found that seizures can cause a certain degree of cognitive function damage.Many studies select wislar mouse simulating human temporal lobe epilepsy model to study the mechanisms of epileptic seizures and cognitive impairment,and COX-2 inhibitors became a research hotspot in recent years since it might interfere the onset and prognosis of epilepsy.Here is to make a review on COX-2 and its inhibitors impact on the onset of epilepsy and cognitive function.

关 键 词：癫痫 环氧化酶2抑制剂 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]