偏头痛发作期伴发的非头痛症状临床分析  

Non-headache symptoms in a migraine attack

作　　者：齐晶晶[1] 姚刚[1] 毛西京[1] 于挺敏[1] 

机构地区：[1]吉林大学第二医院神经内科,长春130041

出　　处：《中华神经医学杂志》2012年第2期173-176,共4页Chinese Journal of Neuromedicine

摘　　要：目的探讨偏头痛患者头痛发作期伴随的非头痛症状的类型、发生率及与其他因素之间的关系。方法选择吉林大学第二医院神经内科头痛门诊自2010年1月至2011年1月诊治的先兆偏头痛（MA）和无先兆偏头痛（MOA）患者71例，分析并比较不同偏头痛患者头痛发作期伴随的非头痛症状数和性别、偏头痛亚型对非头痛症状发生率的影响。结果年龄、性别、受教育水平、偏头痛亚型、头痛程度、平均每月的发作次数不同的偏头痛患者之间非头痛症状数的差异无统计学意义（P〉0．05）；偏头痛患者最常见的非头痛症状是恶心（87-3％），其次是畏声（81．7％）和情绪改变（69．0％）。MOA患者畏声、睡眠障碍、畏嗅的发生率高于MA患者，差异有统计学意义（P〈0．05）。结论偏头痛患者（伴或不伴先兆）头痛发作期存在多种多样的非头痛症状，其中以恶心、畏声及情绪改变的发生率最高，MOA患者畏声、睡眠障碍、畏嗅的发生率高于MA患者。Objective To characterize non-headache symptoms during the migraine attack phase in migraine patients. Methods We enrolled in the present investigation 71 patients with migraine with and without aura who had sought medical treatment in our department from January 2010 to January 2011. We used a self-made migraine questionnaire to investigate associations of the non-headache symptoms with the sociodemographic factors, subtypes, severities and attacks of the headache in the patients. Results There were no significant differences in the number of non-headache symptoms among patients with different ages, genders, education levels, subtypes, severities, mean attack frequencies per month （P〉0.05）. The most frequently reported non-headache symptoms were nausea （87.3%）, phonophobia （81.7%） and mood change （69.0%）. The incidences ofphonophobia, sleep disorder and osmophobia were significantly higher in patients without aura than in patients with aura （P〈0.05）. Conclusion Migraine attacks are often accompanied by a variety of non-headache symptoms of which the most frequently reported ones are nausea, phonophobia and mood change. Patients without aura tend to have more phonophobia, sleep disorder and osmophobia than those with aura.

关 键 词：偏头痛 非头痛症状 发病机制 

分 类 号：R747.2[医药卫生—神经病学与精神病学]