15例伴1lp15异常急性髓系白血病患者的临床特征分析  

Clinical analysis on 15 acute myeloid leukemia patients with llp15 abnormalities

作　　者：汪琼[1] 陆滢 牧启田 陈志妹[3] 楼基余[3] 金洁[1] 

机构地区：[1]宁波大学医学院,315400 [2]宁波市宁波第一医院 [3]浙江大学医学院附属第一医院血液科、浙江大学血液病研究所

出　　处：《中华血液学杂志》2012年第2期76-78,共3页Chinese Journal of Hematology

摘　　要：目的分析伴11p15异常的急性髓系白血病（AML）患者细胞遗传学和临床特征，并探讨其对预后的影响。方法回顾性分析1994至2010年于浙江大学医学院附属第一医院住院及门诊伴1lpl5异常AML患者的临床及实验室资料，并进行预后分析。结果在1725例初发AML患者中检出15例1lpl5异常，检出率为0．87％，其中t（7；11）异常6例，t（1；11）和t（11；12）异常各2例，t（2；11）、t（11；11）、t（11；14）、del（11）及inv（11）异常各1例。15例1lpl5异常患者中，M210例，M，3例，M。和M。各1例。6例t（7；11）异常患者均为M：型，其中5例患者白血病细胞可见Auer小体。15例患者中12例进行了化疗，7例获得缓解，但中位持续完全缓解时间仅为8（4-12）个月；其中13例患者均已死亡，中位生存期为11（2-19）个月。结论1lpl5异常为AML中少见的再现性染色体异常，以t（7；11）最常见，并有独特的临床及实验室特征；伴11p15异常的AML患者治疗效果差，预后不良。Objective To analyze the cytogenetic and clinical features of acute myeloid leukemia （AML） with 11p15 abnormalities and explore its influence on prognosis. Method The clinical and laborato- ry data of AML patients with 11 p15 abnormalities from the First Affiliated Hospital of Zhejiang University from 1994 to 2010 were collected and their prognosis was analyzed. Results 15 （0.87%） out of 1725 de novo AML had abnormalities of llp15, of which 6 cases involved t（7 ;11 ）, 2 had t（ 1 ;11 ） and 2 had t（ 11 ;12）. And others manifested t（2; 11 ）, t（ 11 ; 11 ）, t（ 11 ;14）, del （ 11 ） or inv （ 11 ） respectively. The FAB type of 15 cases with 11 p15 abnormalities were Me （ 10 cases）, M5 （ 3 cases）, M1 （ 1 case） and M4 （ 1 case）. ALL 6 cases with t（7 ; 11 ） were M2 , 5 of them showed of Auer rods in myeloid blasts. 12 of 15 patients had received chemotherapy, and 7 patients obtained complete remenssion （ CR）, the median duration of CR was only 8 months （4 -12 months） ; Of the 15 patients, 13 died, and the median overall survival （MS） was 11 months （2 - 19 months）. Conclusions llp15 abnormalities is a rare recurring chromosomal aberration in AML of which the of with the most commonly seen is t（7;11 ）, which has its unique clinical and laboratory character- istics. AML patients with llp15 abnormalities had a poor prognosis.

关 键 词：llpl5异常 核型分析 白血病 非淋巴细胞 急性 预后 

分 类 号：R733.7[医药卫生—肿瘤]