左乙拉西坦单药治疗老年癫癎的临床研究  

Clinical study on seniors with epilepsy treated by levetiracetam as monotherapy

作　　者：蒋萍[1] 刘骅[1] 刘沁[1] 郑丽华[1] 

机构地区：[1]宜宾市第二人民医院神经内科,四川宜宾644000

出　　处：《癫痫与神经电生理学杂志》2012年第1期36-38,共3页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：研究左乙拉西坦（LEV）治疗老年癫癎患者的临床疗效、安全性及对生活质量的影响.方法：采用前瞻性研究对42例不同类型老年癫癎患者（男24例,女18例;年龄60～82岁）,使用LEV单药治疗.LEV起始剂量：500 mg,每日2次,根据疗效调整剂量,比较不同发作类型老年癫癎患者的疗效、安全性及对生活质量的影响.结果：42例老年癫癎患者用LEV后无发作13例（31%）,显效9例（22%）,有效14例（33%）,无效6例（14%）,采用癫癎患者生活质量量表-31（QOLIE-31）评定,LEV治疗后在对发作的担忧、精力/疲乏、认知功能、药物影响及社会功能方面得分与治疗前比较差异有统计学意义（P〈0.05）,有7例（17%）出现与LEV可能有关的不良反应,其中嗜睡2例,急躁3例,注意力不集中、攻击行为各1例,上述不良反应均未经特殊处理,在1～2个月内自行消失,无1例因不良反应退出治疗.结论：LEV单药治疗各型老年癫癎均有疗效,显著减少发作频率,安全耐受性好,无明显认知毒性,能够提高老年癫癎患者的生活质量.Objective：To observe the effect of levetiracetam（LEV） as monotherapy on the clinical efficacy, safety and quality of life （QOL） in seniors patients with epilepsy. Methods： Prospective study of 42 patients with different types of epilepsy （24 males and 18 females; aged from 60 to 82 years）. LEV monotherapy was used. The initial dosage was 500 mg bid. And then it was adjusted based on the efficacy. The treatment efficacy,safety and impact in QOL were compared among different types of aged patients with epilepsy. Results： Thirteen cases （31%） in 42 patients became seizure free, 9 cases （22%） were significantly effective , 14 （33% ） were effective, 6 （33 %） were ineffective. QOL questionnaire in patients with epilepsy-31 （QOLIE-31） assessment,after treatment with LEV, the scores about seizure concerns, energy/fatigue, cognitive function, the influence of drugs and social function were statistically significant （P〈0. 05）, Adverse reactions retaed to LEV were presented in 7 cases （17%）, inclading drowsiness in 2 cases, impatience in 3 cases, lack of concentration in 1 case and, aggressive behavior in 1 case. These adverse reactions were not specially treated and disappeared within 1 - 2 months. None of the cases with adverse reaction gave up the treatment. Conclusion：LEV monotherapy for epilepsy is effective for aged patients with epilepsy in seizure frequency, and safety, LEV can improve the quality of life of aged patients with epilepsy, without significant cognitive toxicity.

关 键 词：左乙拉西坦 单药治疗 癫癎 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]