A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population  

作　　者：Qiang Yu,Chun-Xiao Zhou,Nan-Sheng Chen,Shu-Dan Zheng,Li-Ming Shen,Jin-Kun Zhang,Department of Gastroenterology,Suzhou Municipal Hospital,Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215002,Jiangsu Province,China 

出　　处：《World Journal of Gastroenterology》2012年第4期383-387,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by The Applied Basic Research Programs of Science and Technology Commission Foundation of Suzhou,No.sys201047

摘　　要：AIM:To investigate the association between hepatocel-lular carcinoma (HCC) susceptibility and a 12-bp inser-tion/deletion polymorphism (rs6147150) in the 3'UTR of ErbB4.METHODS:Using a case-control design,the rs6147150 genotypes in 270 patients with HCC and 270 healthy controls were determined by direct polymerase chain reaction and polyacrylamide gel electrophoresis.Logistic regression was used to analyze the association between the polymorphism and cancer risk.RESULTS:Computational modeling suggested that rs6147150 was located in the seed region of hsa-let-7c,a potential target sequence in ErbB4 3'UTR.Logistic re-gression analysis showed that,compared with individu-als homozygous for wild-type,heterozygotes [adjusted odds ratio (OR)=1.48,95% confidence interval (CI)= 1.03-2.17,P=0.034] and individuals homozygous for 12-bp del/del (OR=2.50,95% CI=1.37-4.56,P=0.001) were at significantly higher risk of HCC.Car-riers of the "del" allele of rs6147150 had a 1.59-fold increased risk for HCC (95% CI=1.22-2.07,P=0.003).CONCLUSION:rs6147150 may be associated with HCC risk,in part through let-7c-mediated regulation,and may be involved in the pathogenesis of HCC in Chi-nese populations.AIM：To investigate the association between hepatocel-lular carcinoma （HCC） susceptibility and a 12-bp inser-tion/deletion polymorphism （rs6147150） in the 3＇UTR of ErbB4.METHODS：Using a case-control design,the rs6147150 genotypes in 270 patients with HCC and 270 healthy controls were determined by direct polymerase chain reaction and polyacrylamide gel electrophoresis.Logistic regression was used to analyze the association between the polymorphism and cancer risk.RESULTS：Computational modeling suggested that rs6147150 was located in the seed region of hsa-let-7c,a potential target sequence in ErbB4 3＇UTR.Logistic re-gression analysis showed that,compared with individu-als homozygous for wild-type,heterozygotes [adjusted odds ratio （OR）=1.48,95% confidence interval （CI）= 1.03-2.17,P=0.034] and individuals homozygous for 12-bp del/del （OR=2.50,95% CI=1.37-4.56,P=0.001） were at significantly higher risk of HCC.Car-riers of the ＂del＂ allele of rs6147150 had a 1.59-fold increased risk for HCC （95% CI=1.22-2.07,P=0.003）.CONCLUSION：rs6147150 may be associated with HCC risk,in part through let-7c-mediated regulation,and may be involved in the pathogenesis of HCC in Chi-nese populations.

关 键 词：Hepatocellular carcinoma ERBB4 rs6147150 Insertion/deletion polymorphism 

分 类 号：R735.7[医药卫生—肿瘤]