创伤合并SIRS患者血清α-MSH与APACHEⅡ评分的关系  

Relationship between Serum α-MSH and APACHE Ⅱ Score in Trauma Patients

作　　者：周强[1] 冯贵龙[1] 杨晓明[1] 杜晓东[1] 

机构地区：[1]山西医科大学第一医院,太原030001

出　　处：《医学研究杂志》2012年第1期104-106,共3页Journal of Medical Research

摘　　要：目的探讨创伤患者血清α-MSH与APACHEⅡ评分的关系及在病程监测中的意义。方法选择50例创伤合并全身炎症反应综合征(SIRS)患者,按照入院时APACHEⅡ评分分为轻度创伤组(22例,≤15分)和重度创伤组(28例,>15分),分别在入院的第1、3、5、7天动态检测血清α-MSH浓度的变化,采用酶联免疫吸附试验(ELISA)检测血清α-MSH含量,并同步进行APACHEⅡ评分,对所得结果进行统计学分析。结果患者入院时轻度创伤组与重度创伤组比较,血清α-MSH含量水平差异有统计学意义(P<0.05);两组患者血清α-MSH水平随后变化不明显,重度组保持在较低水平,两组间同一时间点比较,差异有统计学意义(P<0.01或P<0.05)。入院时APACHEII评分两组间有差别,此后两组间APACHEⅡ评分各时间点比较,差异有统计学意义(P<0.01或P<0.05)。结论动态检测创伤患者血清α-MSH水平结合APACHEⅡ同步评分,有助于准确及时地评估病情。To investigate the relationship between serum a - MSH and APACHE Ⅱ score in Trauma patients. Methods A clinical prospective self - control trial was performed. 50 patients with SIRS were enrolled, and were divided into mild （ ≤ 15 ） or severe trauma group（ 〉 15） according to APACHE Ⅱ score. The a - MSH concentrations were determined on the 1 st, 3rd, 5th,7th day after ad- mission and the APACHE Ⅱ score were assessed at the same time. The concentrations of a - MSH measured by enzyme linked immunosor- bent assay （ELISA）. Results The concentrations of a - MSH in severe trauma group were higher than those in the mild trauma groups after trauma （P 〈 0.05）. Then serum a - MSH level in the two groups did not change significantly, and the severe group remain low. There was significant difference （P 〈 0.01 or P 〈 0.05） in the indexes between the two groups at the same time. The APACHE Ⅱ score was significantly different between the two groups after trauma. Then APACHE Ⅱ score in the two groups had a significant difference （P 〈 0.01 or P 〈 0.05 ）. Conclusion Dynamic measurement of a - MSH concentrations with APACHE Ⅱ scores can help evaluate the se- verity of critical patients.

关 键 词：Α-MSH APACHEⅡ评分 SIRS 

分 类 号：R576[医药卫生—消化系统]