顶空毛细管气相色谱法测定盐酸头孢卡品酯中的残留有机溶剂  

Determination of residual solvent in cefcapene pivoxil hydrochloride by headspace gas chromatography

作　　者：程奇珍 肖小武[1,2] 罗跃华 易路遥 熊蔚 

机构地区：[1]江西省食品药品检验所 [2]南昌大学药学院

出　　处：《中国抗生素杂志》2012年第2期120-122,共3页Chinese Journal of Antibiotics

摘　　要：目的建立盐酸头孢卡品酯中7种有机溶剂的分离测定方法。方法采用顶空进样毛细管气相色谱法,FID检测器,运用DB-1毛细管柱(30.0m×0.53mm,1.5μm)为色谱柱,氮气为载气,采取程序升温,初始柱温40℃,保持10min,再以20℃/min的速率升至80℃,保持5min。测定了盐酸头孢卡品酯中丙酮、乙醇、乙酸乙酯、二氯甲烷、甲基异丁基酮、四氢呋喃和N、N-二甲基甲酰胺的残留量。结果各有机溶剂均能得到有效的分离,在所考察的溶度范围内线性关系良好,R2为0.9988～0.9999,平均回收率为96.7%～103.3%。结论本方法灵敏、准确、可靠,可用于盐酸头孢卡品酯的质量控制。Objective To eastablish a method for determination or seven residual solvents m cefcapene plvoxil hydrochloride. Methods Using DB-1 capillary column （30.0m×0.53mm, 1.5pm）, FID detector and programably tempreture .The initial tempreture was kept at 40℃ for 10 min, and the tempreture was raised to 80℃ at rate of 20℃/ min and lasted 5 min. Results Seven residual solvents were completely separated and there were good linearies （R2=0.9988-0.9999）. The average recovery rate was in the range of 96.7%-103.3%. Conclusion The methods proved to be accurate and sensitive, thereby available for quality control.

关 键 词：顶空毛细管气相色谱法 盐酸头孢卡品酯 残留溶剂 

分 类 号：R978.11[医药卫生—药品]