术前高危型HPV载量与CIN2、CIN3患者LEEP术后病灶残留或复发的相关性  

The correlation between viral load of high-risk human papilloma virus and remains or recidivation after loop electrosurgical excision procedure treatment for CIN 2,CIN 3 patients

作　　者：林琳[1] 陈艳 曹华妹[1] 郑乐荣[1] 郝力[1] 王步补 

机构地区：[1]浙江省瑞安市人民医院妇产科,浙江瑞安325200 [2]浙江省瑞安市人民医院病理科,浙江瑞安325200

出　　处：《中国现代医生》2012年第5期85-87,共3页China Modern Doctor

基　　金：浙江省温州市医药卫生科研项目(2011B061)

摘　　要：目的探讨术前高危型HPV载量与CIN2、CIN3患者LEEP术后病灶残留或复发的关系。方法筛查35 437例门诊患者,532例CIN2、CIN3患者行LEEP术治疗,术后3、6、9、12个月时复查高危型HPV DNA及宫颈TCT。结果高危型HPV阳性率为15.17%;各病理类型高危型HPV载量之间有显著差异(P<0.05);高危型HPV载量与CIN病理类型间呈正相关(P<0.05);不同高危型HPV载量组之间CIN病灶残留或复发率有显著差异(P<0.01);高危型HPV高载量是CIN2、CIN3患者LEEP术后病灶残留或复发的危险因素(OR=1.357、1.442)。结论高危型HPV载量与CIN的发生、进展及CIN2、CIN3患者LEEP术预后有关。Objective To investigate the correlation between viral load of high-risk HPV and remains or recidivation after LEEP treatment for CIN 2, CIN 3 patients. Methods Screened 35 437 outpatients, 532 cases of CIN 2, CIN 3 were given the LEEP treatment, reviewed high-risk HPV DNA and cervix uterus TCT in 3, 6, 9 and 12 months after treatment. Re- suits The positive rate of high-risk 1-IPV was 15.17%. There was Significantly different among the viral load of high-risk HPV in pathological types （P 〈 0.05）. The viral load of high-risk I-IPV was positive correlation with the types of CIN （P 〈 0.05）. There was significantly different among the remains or recidivation rate of different viral load groups （P 〈 0.01）. The high viral load of high-risk HPV was a risk factor of remains or recidivation after LEEP treatment for CIN 2, CIN 3 （OR = 1.357, 1.442）. Conclusion The viral load of high-risk HPV is related to CIN and the prognosis of LEEP treatment for CIN 2, CIN 3 patients.

关 键 词：高危型人乳头状瘤病毒 病毒载量 宫颈上皮内瘤样变 

分 类 号：R737.33[医药卫生—肿瘤]