SIRT1与肿瘤发生  

SIRT1 and Tumorigenesis

作　　者：赵志强[1] 毛文琼[1] 

机构地区：[1]台州学院医学院,浙江台州318000

出　　处：《台州学院学报》2011年第6期48-52,62,共6页Journal of Taizhou University

基　　金：浙江省教育厅科研计划资助项目(Y200907062)

摘　　要：SIRT1(sirtuin 1)通过对肿瘤抑制蛋白和DNA损伤修复蛋白去乙酰化而使之失活。因此,SIRT1早期被认为是肿瘤促进因子。近来研究又表明SIRT1在某些肿瘤中表达降低且SIRT1缺乏导致遗传不稳定和肿瘤发生。超表达SIRT1可降低癌变风险。SIRT1的这种双重作用可能与其组织中SIRT1上游和下游因子的时空分布不同有关。Sirtuin l（SIRT1）inactivates proteins involved in tumor suppression and DNA damage repair ）by deacetylation and it has long been considered as a tumor promoter. However, recent studies demonstrated that SIRT1 expression levels are reduced in some other types of cancers, and that SIRT1 deficiency results in genetic instability and tumorigenesis,while overexpression of SIRT1 attenuates cancer formation. The dual role that SIRT1 plays may depend on the temporal and special distribution of different SIRT1 upand downstream factors in different tissue contexts.

关 键 词：SIRT1 肿瘤发生 肿瘤促进因子 肿瘤抑制因子 

分 类 号：R730.2[医药卫生—肿瘤]