个体化切削准分子激光原位角膜磨镶术后泪膜改变的研究  

Investigation of changes in the tear film stability after individualized LASIK

作　　者：彭燕一[1] 秦贤杰[1] 张文彬[1] 廖妙云[1] 易冰琰[1] 

机构地区：[1]桂林医学院附属医院眼科,广西桂林541001

出　　处：《华夏医学》2011年第4期431-434,共4页Acta Medicinae Sinica

基　　金：桂林市科学研究与技术开发项目(编号:20070213-2)

摘　　要：目的:观察最优化屈光性角膜切削术(optimized refractive keratectomy,ORK)后泪液分泌、泪膜稳定性的改变,分析其与干眼的关系。方法:随机选择80名近视眼患者实施双眼ORK手术,分别用荧光素法和schirmerⅠ试验(基础分泌试验)测定患者术前、术后1周、1个月、3个月、6个月的泪膜破裂时间(break up time,BUT)和泪液分泌值。结果:①schirmer值(单位:mm):术前为18.22±5.29,术后1周、1个月、3个月、6个月分别为8.06±2.81,10.30±3.22,13.24±3.72,16.80±4.48;术后1周、1个月、3个月和6个月Schirmer值分别与术前比较,差异有显著性意义(P<0.01)。②BUT值(单位:s):术前为19.68±5.77,术后1周、1个月、3个月、6个月分别为9.69±2.91,12.11±3.32,14.99±4.15,18.83±5.05;术后1周、1个月、3个月和6个月分别与术前的BUT值比较,差异均有显著性意义(P<0.01)。结论:ORK术后6个月内,泪膜稳定性下降及泪液分泌减少,但有逐渐恢复的趋势。Objective： To investigate the changes in tear secretion and tear film stability after optimized refractive keratectomy（ORK）.Methods： 80 patients who would undergo ORK of double eyes were randomly assigned to take fluorescein method and SchirmerⅠtest（basic secretion test） for measuring tear film break-up time（BUT） and value of tear secretion at pre-operation and 1 week,1 month,3 months,6 months after operation.Results： ① Mean Schirmer values（unit： mm） were 18.22±5.29 for pre-operation;8.06±2.81,10.30±3.22,13.24±3.72,16.80±4.48 for after operation 1 week,1 month,3 months,6 months.The pre-operation tear secretion value was significantly higher than that of 1 week,1 month,3 months,6 months after the operation（P0.01）.②Mean BUT values were 19.68±5.77 for pre-operation,9.69±2.91,12.11±3.32,14.99±4.15,18.83±5.05 for after operation 1 week,1 month,3 months,6 months respectively,compared the pre-operation value with that of 1 week,1 month,3 months,6 month after the operation,the differences were statistically significant（P0.01）.Conclusions： All patients can gradually recover with both tear film stability and tear secretion decreased in 6 months after ORK.

关 键 词：准分子激光原位角膜磨镶术 泪膜破裂时间 泪液分泌值 

分 类 号：R779.63[医药卫生—眼科]