2-硫代-4-噻唑酮与查尔酮的无溶剂Michael加成反应  

Synthesis of solvent-free Michael addition reaction of 2-thio-4-thiazolidinone with chalcon

作　　者：冯驸[1] 黎云攀[1] 周红艳[1] 胡卫兵[1] 

机构地区：[1]湖北民族学院化学与环境工程学院,湖北恩施445000

出　　处：《化学试剂》2012年第2期177-178,181,共3页Chemical Reagents

基　　金：湖北省高等学校优秀中青年科技创新团队计划资助项目(T201006)

摘　　要：以查尔酮和2-硫代-4-噻唑酮为原料,在NaOH存在下无溶剂室温研磨反应,非常方便合成了系列未见文献报道的Michael加成产物。该方法具有反应条件温和、操作简单和产率较高等优点,并通过IR、HNMR、MS和元素分析确证产物的结构。A series of novel Michael addition products of 2-thio-4-thiazolidinone to chalcone were obtained in the presence of sodium hydroxide under solvent-free condition.The advantages of this procedure were mild reaction conditions,simple protocol,and high yields.The structures of the products were confirmed by IR,1HNMR,MS and elemental analysis.

关 键 词：查尔酮 MICHAEL加成 无溶剂 

分 类 号：O622[理学—有机化学]