固相萃取-液相色谱-串联质谱法检测化妆品中的双酚A残留  

Determination of bisphenol a residues in cosmetics by solid phase extraction-liquid chromatography-tandem mass spectrometry

作　　者：王浩[1] 杨红梅[1] 刘艳琴[1] 史海良[1] 郭启雷[1] 刘婷[1] 闫龙宝[1] 

机构地区：[1]北京市海淀区产品质量监督检验所,北京100094

出　　处：《分析试验室》2012年第2期67-70,共4页Chinese Journal of Analysis Laboratory

基　　金：国家质检总局质检公益性行业科研专项资助项目(201010048)资助

摘　　要：建立了化妆品中双酚A残留的高效液相色谱-串联四极杆质谱联用测定方法。样品经碱性乙腈提取,氨基固相小柱净化而后测定。方法在2.0～100.0μg/L范围内呈良好线性,相关系数为0.99998,方法的检出限为0.02 mg/kg。在0.10,1.0,10.0 mg/kg 3个加标水平下,加标回收率为92.4%～98.8%,相对标准偏差为6.0%～9.4%。A LC-MS-MS method was developed for the determination of bisphenol A residues in cosmetics.The sample was extracted by alkaline acetonitrile in ultrasonic,then cleaned up by NH2 solid-phase extraction cartridge and analyzed by LC-MS-MS.Under the optimal conditions,good linear relationship was obtained in the range of 2.0～100.0 μg/L for bisphenol A with correlation coefficient of 0.99998.The limit of detection was 0.02 mg/kg.The recoveries at three spiked levels of 0.10,1.0,10 mg/kg were between 92.4% and 98.8%,and RSDs were between 6.0%and 9.4%.

关 键 词：液质联用仪 化妆品 双酚A 固相萃取 

分 类 号：O657.63[理学—分析化学]