ARHI和环氧化酶-2蛋白在子宫颈腺癌组织中的表达及其意义  

The expression and significance of ARHI and COX-2 protein in tissues of the adenocarcinoma of the uterine cervix

作　　者：赵敏[1] 刘岿然[1] 

机构地区：[1]中国医科大学附属盛京医院第一妇科病房,沈阳110004

出　　处：《中国综合临床》2012年第3期241-244,共4页Clinical Medicine of China

基　　金：辽宁省高等学校科研项目（2008862）

摘　　要：目的探讨ARHI蛋白和环氧化酶-2（COX-2）蛋白在子宫颈腺癌发生中的作用及其相互关系。方法采用免疫组织化学法检测40例子宫颈腺癌及30例慢性子宫颈炎组织中。ARHI蛋白及COX-2蛋白的表达情况。结果ARHI在40例子宫颈腺癌组织阳性率为50．0％（20／40），低于慢性子宫颈炎患者子宫颈组织阳性率90．0％（27／30），差异有统计学意义（X^2=12．43，P〈0．05）；COX-2在40例子宫颈腺癌组织阳性率82．5％（33／40），高于慢性子宫颈炎患者子宫颈组织阳性率0（0／30），差异有统计学意义（x^2=46．16，P〈0．05）；ARHI蛋白阳性表达率与子宫颈腺癌临床分期（x^2=3．96，P〈0．05）及组织分化程度高低有关（x^2=7．04，P〈0．05）。COX-2蛋白与子宫颈腺癌组织分化程度有关（x^2=7．04，P〈0．05），与临床分期无关（P〉0．05）；ARHI蛋白和COX-2蛋白与淋巴结有无转移均无关（P均〉0．05）；ARHI蛋白和COX．2蛋白表达有关联（r=0．31，P〈0．05）。结论子宫颈腺癌的发生与ARHI基因失活和COX-2蛋白表达异常有关，两者可能协同作用参与子宫颈腺癌的发生。Objective To study the role of ARHI protein and COX-2 protein and to explore their correlation in pathogenesis of adenocarcinoma of the uterine cervix. Methods The expression of ARHI and COX-2 protein were detected both in 40 cases of adenocarcinoma of the uterine cervix and in 30 cases of normal cervix by immunohistochemistry. Results The positive rate of the expression of ARHI protein in adenocarcinoma of the uterine cervix was 50. 0% （20/40） ,which lower than that in normol cervix controls 90. 0% （27/30） ,the difference was significant （ X2 = 12. 43, P 〈 0. 05 ） ; The positive rate of the expression of COX-2 protein in adenocarcinoma of the uterine cervix was 82. 5% （33/40）, which higher than that in normol cervix controls 0 （0/ 30）, the difference was significant （X2 = 46. 16, P 〈 0. 05 ） ;The positive expression rate of ARHI was negatively correlated with the clinical stage of cervical adenocarcinoma （ X2 = 3.96, P 〈 0. 05 ） disease and pathological grade （ X2 = 7.04, P 〈 0. 05 ）. COX-2 protein was positively correlated with pathological grade （ X2 = 7. 04, P 〈 0.05 ） ,but had no correlation with the clinical stage of cervical adenocarcinomacervical adenocarcinoma stage of diseas（P 〉 0. 05 ） ;The expression of ARHI protein and COX-2 protein wasn＇t correlated with lymph nodeatic meatastasis（P 〉0. 05）;The expression of ARHI protein had correlation with the expression of COX-2 protein （r = 0. 31 ,P 〈 0. 05 ）. Conclusion Inactivation of ARHI gene and the abnormal expression of COX-2 protein are involved in the origin of cervical adenocarcinom tumor origin of cervical adenocarcinoma.

关 键 词：ARHI蛋白 COX-2蛋白 子宫颈腺癌 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]