血浆置换治疗高脂血症性急性胰腺炎临床效果观察  

Therapeutic effect of plasmapheresis in treatment of hyperlipidemic acute pancreatitis

作　　者：许少英[1] 李绪城[1] 

机构地区：[1]广东省汕头市中心医院血液净化中心,515031

出　　处：《中国综合临床》2012年第3期279-281,共3页Clinical Medicine of China

摘　　要：目的探讨血浆置换治疗高脂血症性急性胰腺炎的临床效果。方法回顾性分析24例高脂血症性急性胰腺炎患者的临床资料，使用常规治疗合并血浆置换治疗，比较分析血浆置换治疗前后患者临床症状、血脂（甘油三酯、胆固醇）浓度变化以及患者预后等。结果24例患者中1例手术后行血浆置换治疗，1例极重症血浆置换治疗后再行手术治疗，余22例未行手术治疗。24例患者经血浆置换治疗后症状均有减轻、血脂浓度明显下降，甘油三酯从治疗前（24．55±10．76）mmol／L降到治疗后（3．85±3．02）mmol／L，差异有统计学意义（t=7．099，P〈0．01）；胆固醇从治疗前（10．82±5．06）mmol／L降到治疗后（3．43±1．28）mmol／L，差异有统计学意义（t=5．826，P〈0．01）。24例均治愈出院。结论血浆置换治疗高脂血症性急性胰腺炎安全、有效。Objective To investigate the clinical effect of plasmapheresis in the treatment of hyperlipidemic acute pancreatitis. Methods Twenty four patients with hyperlidemic acute panereatitis were treated with plasmapheresis combined with the conventional therapeutic measures. The clinical symptoms, serum levels of lipids （triglycerides, cholesterol） and the prognosis of patients were observed and compared before and after the treatment of plasmpheresis. Results One case underwent plasmapheresis after surgery, one case with extremely severe symptoms underwent surgical treatment after plasmapheresis,twenty two cases didn＇t underwent surgical treatment. After the plasmapheresis treatment the clinical symptoms of twenty four patients were alleviated and the blood lipid levels decreased significantly. The triglyceride concentrations decreased significantly from（24. 55 ±10. 76） mmol/L to （3.85 ± 3.02 ） mmol/L （ t = 7. 099, P 〈 0. 01 ） and the cholesterol concentrations decreased significantly from （ 10. 82 ± 5.06 ） mmol/L to （ 3.43 ± 1.28 ） mmol/L （ t = 5. 826, P 〈0. 01 ）. Twenty four cases of patients were cured and discharged. Conclusion It is safe and effective of plasmapheresis in treatmeat of hyperlipidemic acute pancreatitis.

关 键 词：血浆置换 高脂血症 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]