四逆泡腾片中挥发油提取及包合工艺  

Extraction of Volatile Oil and Preparation Technology of β-Cyclodextrin Inclusion from Sini Effervescent Tablet

作　　者：傅亮[1] 饶小勇[2] 黄恺[2] 徐兰[1] 桂婵[1] 封传华[1] 饶涛[1] 罗晓健[1,2] 

机构地区：[1]江西中医学院,南昌330004 [2]中药固体制剂制造技术国家工程研究中心,南昌330006

出　　处：《中国实验方剂学杂志》2012年第4期5-9,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2009ZX09310-005)

摘　　要：目的:研究四逆泡腾片中干姜油的提取及其β-环糊精包合的最佳工艺。方法:运用正交试验考察加水倍量、浸泡时间、蒸馏时间对挥发油提取量的影响;对胶体磨法、饱和水溶液法、超声法进行比较试验,以挥发油包合率、包合物收得率和包合物含油率为综合评价指标,选择最佳包合方法;采用正交试验法优选胶体磨法的最佳包合工艺,并对包合物进行验证。结果:最佳提取工艺为药材不浸泡、加6倍量水、蒸馏8 h;胶体磨法的最佳包合工艺为挥发油与β-环糊精按(1 mL∶8 g)投料、包合时间45 min,加水量80 mL。结论:胶体磨法包合干姜挥发油,工艺简单、可行,适合工业化大生产。Objective：To study on extraction process of volatile oil from dried ginger and its inclusive compound by β-cyclodextrin（β-CD） from Sini effervescent tablet.Method：Orthogonal test was employed to investigate effect of water volume,soak time and distilled time on extraction of volatile oil;and took comparative test of saturated water solution method,colloid mill method,and ultrasound method,choose optimum inclusion method with inclusion efficiency of volatile oil,yield of inclusion and the content of oil in inclusion as comprehensive indexes;Optimum inclusion technology of colloid mill method was optimized by orthogonal test,and validate inclusion compound.Result：Optimum extraction technology conditions were to add 6 times the amount of water,and distilled 8 h without soaking;Optimum inclusion technology of colloid mill method was as follows：proportion of volatile oil to β-CD was 1∶8（mL∶g）,inclusion time was 45 min;the amount of water was 80 mL.Conclusion：Inclusion technology（colloid mill method）of volatile oil from dried ginger was simple,feasible and appropriated for large-scale production.

关 键 词：干姜油 提取 胶体磨 Β-环糊精 正交设计 多指标 

分 类 号：R283.6[医药卫生—中药学]