柴菊口服液的抗病毒抑菌和抗炎解热作用  

Antiviral,antibacterial,anti-inflammatory and antipyretic effects of Chaiju oral liquid

作　　者：吴虓飞[1] 金翠英[1] 吴子伦[2] 回连强[2] 周建平[1] 王志斌[1] 

机构地区：[1]北京市药品检验所药物安全评价中心,北京100035 [2]中国中医科学院中药研究所,北京100700

出　　处：《中国新药杂志》2012年第2期164-169,共6页Chinese Journal of New Drugs

摘　　要：目的:考察柴菊口服液抗病毒抑菌和抗炎解热作用。方法:采用细胞病变抑制法、琼脂稀释法、小鼠流感病毒感染法来研究柴菊口服液对常见呼吸道病毒和细菌的抑制作用;采用小鼠耳廓肿胀法、小鼠腹腔致炎法和细菌内毒素致家兔发热法研究柴菊口服液的抗炎解热作用。结果:柴菊口服液对流感病毒甲3型(A3)、副流感病毒1型(HVJ)、呼吸道合胞病毒(RSV)、单纯疱疹病毒1和2型(HSV-1,HSV-2)以及所试6种细菌56株菌株均有不同程度的抑制作用,其中对副流感病毒和金葡菌的抑制作用较强。高、中、低剂量(19.2,9.6,4.8 g生药.kg-1)柴菊口服液能不同程度降低流感病毒感染小鼠的肺指数(P<0.01或0.05),增加感染小鼠的体重(P<0.05),减少感染小鼠的死亡率(P<0.05),延长感染小鼠的存活时间(P<0.01或0.05);高中剂量柴菊口服液能显著抑制二甲苯引起的小鼠耳廓炎性肿胀(P<0.05);高、中、低剂量柴菊口服液能够明显降低醋酸引起的小鼠腹腔毛细血管通透性(P<0.01或0.05);高剂量(19.2 g生药.kg-1)柴菊口服液对细菌内毒素引起的家兔体温升高有较好的解热作用(P<0.05)。结论:柴菊口服液具有较明显的抗病毒抑菌和抗炎解热功效。Objective： To investigate the antiviral,antibacterial,anti-inflammatory and antipyretic effects of Chaiju oral liquid.Methods： To assess the antiviral and antibacterial effects,cytopathic effects（CPE） method,agar dilution method,and mouse model of infection with flu virus were used.To assess the anti-inflammatory and antipyretic effects,the inflammation was induced by dimethylbenzene（auricle smear method） and intraperitoneal injection of acetic acid in mice,and fever model induced by bacterial endotoxin in rabbits were established.Results： Chaiju oral liquid had inhibitory effect on A3,HVJ,RSV,HSV-1 and HSV-2 viruses,and all the tested bacteria in vitro.The inhibitory effect was more obvious on infections with HVJ and Staphylococcus aureus;Chaiju oral liquid（19.2,9.6 and 4.8 g·kg-1） significantly reduced the lung index of mice infected by virus（P0.01 or 0.05）.It at 19.2 g·kg-1 obviously increased the body weight（P0.05） and reduced mortality（P0.05）;19.2 and 9.6 g·kg-1 significantly prolonged survival time（P0.01 or 0.05） in the infected mice.In addition,Chaiju oral liquid reduced mouse ear edema induced by dimethylbenzene（P0.05）,inhibited the increased vascular permeability caused by acetic acid（P0.01 or 0.05）,and prevented rabbit fever induced by bacterial endotoxin（P0.05）.Conclusion： Chaiju oral liquid has the antiviral,antibacterial,anti-inflammatory and antipyretic effects.

关 键 词：柴菊口服液 抗病毒 抑菌 抗炎 解热 

分 类 号：R932[医药卫生—生药学]