慢性牙周炎患者龈沟液IL-6表达与抑郁焦虑心理因素的相关分析  

Relationship between the IL-6 in the gingival crevicular fluid of the chronic periodontitis and the depression-anxiety psychological factor

作　　者：李全[1] 杨建新[1] 莫朝阳[1] 汤晓华[1] 马国武[1] 杨予[1] 

机构地区：[1]苏州大学附属第二医院口腔中心,江苏苏州215000

出　　处：《中国当代医药》2012年第5期34-35,共2页China Modern Medicine

摘　　要：目的探寻慢性牙周炎患者龈沟液中IL-6表达与抑郁焦虑心理因素关系。方法选择35例慢性牙周炎(chronic periodontitis,CP)患者和34名牙周健康者。采用焦虑自评量表和抑郁症状自评量表进行问卷测评,收集龈沟液,并进行临床牙周检查,采用放射免疫法检测龈沟液中IL-6含量。结果对照组中IL-6总量为(0.16±0.04)ng,慢性牙周炎组为(0.28±0.02)ng。IL-6在慢性牙周炎组的表达高于对照组,P<0.001。在IL-6与抑郁心理指数的线性回归分析中,F=7.430,P=0.009;在IL-6与焦虑心理指数的线性回归分析中,F=7.150,P=0.010。结论在慢性牙周炎组患者龈沟液IL-6总量升高,相对焦虑心理因素,抑郁心理因素与龈沟液IL-6总量相关性更显著。Objective To explore the relationship between the IL-6 in the gingival crevicular fluid （GCF） of the chronic periodontitis （CP） and the depression-anxiety psychological factors. Methods The CP group involved 35 patients while 34 periodontol health volunteers were enrolled as control group. The questionaires of the Self-rating anxiety scale（ASA） and the center for epidemiologic studies depression scale （CES-D） were taken, then the GCF was collected and received the clinical periodontol examination. The amount of IL-6 in the GCF was surveyed by the radio-immunoassay method. Results The amount of IL-6 in the GCF of the control group was （0.16±0.04） ng, while that of the CP was （0.28±0.02） ng. The difference between the CP and the control group was statistically significant （P 0.001）. In the linear regression equation of the IL-6 and the depressive psychological factor got F = 7.430, P = 0.009; The linear regression equation of the IL-6 and the anxiety psychological factor got F = 7.150,P = 0.010. Conclusion The chronic periodontitis get the higher amount of IL-6 of the GCF, compared with the anxiety psychological factor, the depression psychological factor get closer correlation with the IL-6 within CP.

关 键 词：慢性牙周炎 白细胞介素-6 抑郁焦虑心理因素 相关性 

分 类 号：R781.4[医药卫生—口腔医学]