ΔNp63、VEGF和PCNA在膀胱尿路上皮癌中的表达及其与肿瘤浸润和转移的关系  

The relationship of the expression of ΔNp63, VEGF and PCNA with the invasion and metastasis of transitional cell carcinoma of bladder

作　　者：何静华[1] 高放[1] 张凤梅[2] 张秀彬 许华[2] 李胜水[2] 

机构地区：[1]河北省黄骅开发区博爱医院病理科,河北黄骅061100 [2]河北省沧州中西医结合医院病理科,河北沧州061000 [3]河北省南大港医院病理科,河北南大港061103

出　　处：《中国当代医药》2012年第6期12-14,共3页China Modern Medicine

摘　　要：目的探讨ΔNp63、VEGF和PCNA蛋白在膀胱尿路上皮癌组织中的表达及其与癌浸润、转移的关系。方法用免疫组织化学方法检测ΔNp63、VEGF和PCNA的表达,并将三者的表达做相关性分析。结果ΔNp63、VEGF和PCNA在肿瘤组织中的阳性表达率分别为78.7%、58.3%和84.3%;与对照膀胱组织相比,其表达显著增高,差异均有统计学意义(P<0.01);且病理分级高级别、浸润性尿路上皮癌及有淋巴结转移的患者的阳性率显著高于病理分级低级别、浅表性尿路上皮癌及无淋巴结转移的患者,差异均有统计学意义(P<0.05)。结论ΔNp63、VEGF和PC-NA的过表达与膀胱尿路上皮癌浸润转移相关,且三者在其浸润转移中关系密切。Objective To investigate the expression of ΔNp63,VEGF and PCNA in transitional cell carcinoma of bladder （TCCB） and their relationship with the invasion and metastasis of TCCB. Methods The expressions of ΔNp63, VEGF and PCNA on pathological sections of 108 patients with TCCB were detected with immunohistochemical staining. The immunoassay results were analyzed in relation to the tumor stage, grade and the clinical prognosis. Results ΔNp63, VEGF in tumor tissue of PCNA and positive expression rate were 78.7%, 58.3% and 84.3%; Compared with control bladder tissue, its expression was significantly higher, the differences were statistically significant （P 〈 0.01）; And pathology classification high level, invasive urothelial carcinoma and a lymph node metastasis of positive patients significantly higher than the low level pathology classification, superficial urothelial carcinoma and without lymph node metastasis of the patients, the dif- ferences were statistically significant （P 〈 0.05）. Conclusion The over expression of ΔNp63, VEGF and PCNA have a close relationship with the invasion and metastasis of TCCB.

关 键 词：膀胱尿路上皮癌 ΔNP63 VEGF PCNA:免疫组化 

分 类 号：R737.14[医药卫生—肿瘤]