联苯羰基丙酸的合成工艺研究  

Study on Synthesis Technology of 3-(4-Biphenylycarbonyl)propionic acid

作　　者：孟祥福[1] 

机构地区：[1]承德石油高等专科学校化学工程系,河北承德067000

出　　处：《河北化工》2012年第2期20-21,共2页Hebei Chemical Industry

摘　　要：对联苯羰基丙酸的合成工艺进行了研究,发现该反应适宜的溶剂为1,2-二氯乙烷,在用稀硫酸调pH值时,pH<3时便于分离。重结晶适宜工艺条件:以3∶2的95%乙醇和水组成的溶剂,粗品的质量与溶剂的体积比为1∶40(g∶mL),回收率为97.5%。To study the synthesis technology of 3-（4-biphenylycarbonyl）propionic acid.The result showed that the suitable reaction solvent was 1,2-dichloroethane and the suitable pH value was under 3.The suitable conditions for the recrystallization were that the solvent was composed of 95% ethanol and water at aproportion of 3∶2,the ratio of solvent volume to crude product mass was 40∶1（mL∶g）,the recovery rate was 97.5%.

关 键 词：联苯羰基丙酸 合成工艺 重结晶 1 2-二氯乙烷 

分 类 号：R914.5[医药卫生—药物化学]