Th1细胞/Th2细胞在口腔扁平苔藓发病机制中的作用  

The function of Th1 cells and Th2 cells in the pathogenesis of oral lichen planus

作　　者：葛娅娜[1] 张成仁[1] 靳慧[1] 王秀梅[1] 

机构地区：[1]哈尔滨医科大学附属第二医院口腔科,150086

出　　处：《免疫学杂志》2012年第3期255-258,共4页Immunological Journal

基　　金：黑龙江省自然科学基金(D201175);黑龙江省政府博士后启动基金(LRB05-279)

摘　　要：口腔扁平苔藓是最常见口腔黏膜疾病之一,发病机制尚不明确,因其具有癌变潜能,WHO将其列为癌前状态。研究发现,Th1细胞/Th2细胞亚群与口腔扁平苔藓的发病密切相关,尤其是Th1/Th2漂移学说与OLP的关系成为近年研究热点。下文针对Th1细胞/Th2细胞在口腔扁平苔藓中的最新研究成果做一综述和展望。Oral lichen planus（OLP） is a common oral mucosal disease in population,but its etiology still remains unknown.OLP has been classified as a precancerous condition for the malignant disease by Word Health Organization（WHO）.Previous studies have demonstrated there is a close relationship between Th1/Th2 subsets and the pathogenesis of OLP,furthermore,Th1/Th2 polarization theory in OLP has attracted more attentions.Here we will review the recently study of Th1/Th2 cells in OLP.

关 键 词：口腔扁平苔藓 CD4+Th细胞 细胞因子 Th1和Th2漂移学说 

分 类 号：R781.5[医药卫生—口腔医学]