高海拔地区少数民族翼状胬肉治疗的临床观察  

Clinical observation on the treatment of pterygium of minority in high altitude area

作　　者：晏理红[1] 冉多军[1] 

机构地区：[1]新疆生产建设兵团农六师奇台医院眼科,中国新疆维吾尔自治区奇台县831800

出　　处：《国际眼科杂志》2012年第2期350-352,共3页International Eye Science

摘　　要：目的:探讨高海拔地区哈萨克族翼状胬肉患者不同方法治疗的效果。方法:将66例69眼患者随机分为两组,分别采用翼状胬肉显微切除加自体角膜缘干细胞移植联合丝裂霉素C术(33例34眼)和翼状胬肉显微切除+丝裂霉素C术(33例35眼),术后随诊1～2d。结果:角膜上皮愈合时间:角膜缘干细胞组为3～5(平均4.5±2.4)d,胬肉切除组5～8(平均6.5±2.6)d,两组比较差异有统计学意义(t=3.317,P<0.05)。角膜缘干细胞组有1眼复发,复发率3%,胬肉切除组8眼复发,复发率为22%,两组比较差异有统计学意义(χ2=4.389,P<0.05)。结论:在高海拔地区,由于气压低、风沙大、干燥、紫外线辐射强等特点,造成少数民族患病率增高。采用胬肉切除加自体角膜缘干细胞移植联合丝裂霉素C治疗,角膜创面修复快,复发率低,是一种安全、有效、值得推广应用的方法。AIM：To investigate the effect on high altitude Kazak patients with pterygium treated with different methods.METHODS：Sixty-six cases（69 eyes） were randomly divided into two groups,using microsurgical excision of pterygium with limbal stem cell transplantation combined with mitomycin C operation（33 cases,34 eyes） and pterygium microscopic resection combined with mitomycin C operation（33 cases,35 eyes） respectively,postoperative follow-up lasted 1-2 years.RESULTS：The corneal epithelial healing time was 3-5（4.5±2.4）days in corneal limbal stem cells group,5-8（6.5±2.6）days in pterygium excision group,there was significant difference between two groups（t=3.317,P0.05）.Corneal limbal stem cell group had 1 eye recurred,the relapse rate was 3%,8 eyes recurred in pterygium excision group,the recurrence rate was 22%,there was significant difference between two groups（χ2 = 4.389,P0.05）.CONCLUSION：At high altitude,due to low air pressure,large wind and sand,drying,and strong ultarvidet radiation,the prevalence rate of minority nationalities increases.Pterygium excision with autologous limbal stem cell transplantation combined with mitomycin C treatment in patients has fast corneal wound healing and low recurrence rate,which is a safe,effective method and worthy of promotion and application.

关 键 词：高海拔地区 翼状胬肉 角膜缘干细胞 丝裂霉素 移植术 

分 类 号：R779.6[医药卫生—眼科]