大肠癌淋巴管形成浸润特点及其临床意义  

Feature of lymphangiogenesis and lymphatic vessel invasion in colorectal cancer and its the clinicopathologic significance

作　　者：陶茜[1] 陈玉刚[1] 郑煦光[1] 杨海涛[1] 

机构地区：[1]唐山市第二医院中心实验室,河北唐山063000

出　　处：《西部医学》2012年第2期239-240,243,共3页Medical Journal of West China

摘　　要：目的探讨大肠癌淋巴管形成、浸润特点及与转移的关系。方法应用淋巴管特异标记物D2-40检测96例大肠癌中心区、周边区及相应正常组织中的淋巴管密度(LVD),观察淋巴管浸润(LVI)情况,结合临床病理参数进行分析。结果大肠癌中心区LVD明显高于周边区及正常组织(P<0.01)。周边区淋巴管具有功能性,其LVI与肿瘤淋巴结转移、TNM分期和肝转移密切相关(P<0.05)。结论大肠癌周边区淋巴管形成与浸润是判断其转移和不良预后的依据。Objective To investigate the feature of lymphangiogenesis and invasion in colorectal cancer and its correlation with metastasis.Methods New lymphatic-specific markers D2-40 was used immunohistochemically to detect lymphatic vessel density（LVD） and invasion（LVI） in the intratumoural and peritumoral areas,and normal tissue from 96 cases of colorectal cancer and analyzed with clinicopathologic parameters of those colorectal cancer.Results Significantly higher LVD was found in the intratumoural area,when comparing with normal and peritumoural areas（P0.01）.Lymphatic vessel of the peritumoural area was functional and peritumoural LVI was significantly associated with lymph-node invasion,TNM stage and liver metastasis（P0.05）.Conclusion lymphangiogenesis and LVI in the peritumoural area may be helpful for evalution of metastasis and poor prognosis.

关 键 词：D2-40 大肠癌 淋巴管形成 淋巴管浸润 

分 类 号：R735.34[医药卫生—肿瘤]