喹唑啉类化合物的合成及其抗肿瘤活性研究进展  

Research Advances in Synthesis and Antitumor Activity of Quinazoline Derivatives

作　　者：佟茂国[1] 

机构地区：[1]贵州大学,贵州贵阳550025

出　　处：《广州化工》2012年第3期17-19,共3页GuangZhou Chemical Industry

摘　　要：喹唑啉类化合物具有良好的抗肿瘤活性,主要通过对表皮生长因子受体、血管内皮细胞生长因子受体或其酪氨酸激酶的抑制作用,从而达到抗癌的功效。综述了近年来该类衍生物的合成及其抗肿瘤活性研究进展。Quinazoline compounds had good antitumor activity,primarily through inhibiting the epidermal growth factor receptor,vascular endothelial growth factor receptor or its tyrosine kinase in order to play anticancer effect.Research advances in synthesis and antitumor activity were reviewed.

关 键 词：喹唑啉 合成 抗肿瘤活性 研究进展 

分 类 号：O622.6[理学—有机化学]