格林-巴利综合征患者血清肿瘤坏死因子α及髓鞘碱性蛋白水平变化  

The change of serum tumor necrosis factor-α and myelin basic protein levels in patients with Guillain-Barre syndrome

作　　者：王月英[1] 

机构地区：[1]河北省馆陶县人民医院心脑一科,河北馆陶057750

出　　处：《中国医药导报》2012年第3期46-47,共2页China Medical Herald

摘　　要：目的探讨格林-巴利综合征患者血清肿瘤坏死因子α（TNF-α）及血清髓鞘碱性蛋白（MBP）的变化情况及两者在格林-巴利综合征发病中的作用。方法选择我院2005~2010年收治的格林-巴利综合征患者30例,作为研究组,选择同期健康体检者30例作为对照组,分别检测各组患者血TNF-α及MBP变化情况,并进行组间及组内比较。结果研究组患者血清TNF-α及MBP水平均高于对照组,差异均有统计学意义（P〈0.05）;在格林-巴利综合征患者中,血TNF-α及MBP水平随病情的加重而升高,且不同病情分级患者上述指标差异有统计学意义（P〈0.05）。结论血清肿瘤坏死因子-α及髓鞘碱性蛋白与格林-巴利综合征患者发病及病情轻重有重要关系,临床密切监测该指标有助于格林-巴利综合征的发现及病情判断。Objective To explore the change of serum tumor necrosis factor-α（TNF-α） and myelin basic protein（MBP） of patients with Guillain-Barre syndrome and discuss the roles of TNF-α and MBP in the morbidity of Guillain-Barre syndrome.Methods 30 cases of patients who were diagnosed with Guillain-Barre syndrome were selected as study group in our hospital from 2005 to 2010,while 30 cases of healthy people were selected as control group during the same period.Serum TNF-α and MBP levels of the two groups were detected and compared in group and between groups respectively.Results Serum TNF-α and MBP levels of study group were higher than that of control group,the differences were statistically significance（P 0.05）.The illness state was worse with the increase of serum TNF-α and MBP levels in patients with Guillain-Barre syndrome,and there were statistically significant differences among patients with different classes of illness state（P 0.05）.Conclusion There is an important relationship between the incidence and severity of Guillain-Barre syndrome and serum TNF-α and MBP level.Closely monitoring the two indicators can help us to identify and determine the illness state of Guillain-Barre syndrome.

关 键 词：格林-巴利综合征 肿瘤坏死因子Α 髓鞘碱性蛋白 

分 类 号：R745.4[医药卫生—神经病学与精神病学]