熊果酸纯化工艺优化  

Optimization of Extraction and Purification Process for Ursolic Acid

作　　者：王建辉[1] 黄婉[2] 李赤翎[1] 

机构地区：[1]长沙理工大学化学与生物工程学院,湖南长沙410114 [2]中国人民大学环境科学学院,北京100872

出　　处：《食品科学》2012年第2期124-126,共3页Food Science

基　　金：第39批留学回国人员科研启动基金项目;湖南省自然科学基金项目(11JJ6025);湖南省科技厅科技计划项目(2010NK3004);湖南省教育厅科学研究项目(10C0391)

摘　　要：为了将熊果酸的纯度自25%提取纯化到98%以上,以熊果酸提取率及其纯度为评价指标,综合考虑乙醇体积分数、溶解温度、料液比及料炭比(原料质量与活性炭质量的比值)对熊果酸提取纯化的影响,并对其提取纯化工艺进行优化。结果表明:熊果酸纯化的最佳工艺条件为乙醇体积分数95%、提取温度80℃、料液比1:20(g/mL)、料炭比2:1,在此条件下熊果酸的提取率为45.68%,纯度达98.55%。In order to improve the purity of ursolic acid,the extraction and purification process of uroslic acid was optimized to explore the effects of ethanol concentration,extraction temperature,material/liquid ratio and material/activated carbon ratio on extraction rate and purity.The results showed that the optimal extraction and purification process conditions were ethanol concentration of 95%,extraction temperature of 80 ℃,material/liquid ratio of 1：20 and material/activated carbon ratio of 2：1.Under the optimal conditions,the extraction rate and purity of uroslic acid were 45.68% and 98.55%,respectively.

关 键 词：熊果酸 提取 纯化 正交试验 

分 类 号：R284.2[医药卫生—中药学]