甘草酸二铵与多烯磷脂酰胆碱治疗非酒精性脂肪性肝炎的疗效比较  

Comparison of efficacies of diammonium glycyrrhizinate and polyene phosphatidylcholine on nonalcoholic steatohepatitis

作　　者：郭秀丽[1] 梁丕霞[1] 徐有青[1] 

机构地区：[1]首都医科大学附属北京天坛医院,北京100050

出　　处：《中国新药杂志》2012年第3期289-292,共4页Chinese Journal of New Drugs

摘　　要：目的:观察甘草酸二铵、多烯磷脂酰胆碱对非酒精性脂肪性肝炎(NASH)临床疗效差异。方法:将100例非酒精脂肪性肝炎患者随机分为A组(n=42)和B组(n=58)两组。A组使用甘草酸二铵;B组使用多烯磷脂酰胆碱,用法均为静滴2周后口服4周。观察两组治疗前后肝功能、血脂、脂肪肝程度(B超)改变情况,并进行统计学分析。结果:治疗结束时,两组肝功能水平较治疗前均有不同程度改善,且A组与B组无统计学差异;B组的甘油三酯,总胆固醇水平明显低于A组,差异有统计学意义(P<0.05),脂肪肝的缓解程度B组明显优于A组,尤其是在重度脂肪肝方面。结论:甘草酸二铵和多烯磷脂酰胆碱均能明显改善NASH的肝损害,但在血脂改善以及脂肪肝程度的缓解方面,多烯磷脂酰胆碱优于甘草酸二铵。Objective： To compare the therapeutic efficacies of diammonium glycyrrhizinate and polyunsaturated phosphatidylcholine on nonalcoholic steatohepatitis （NASH）. Methods： One hundred NASH patients were divided into two groups. They were treated with diammonium glycyrrhizinate （iv for 2 weeks ＋po for 4 weeks, n = 42） , or with polyene phosphatidylcholine （iv for 2 weeks ＋po for 4 weeks, n =58）. Efficacy was evaluated by the indexes including liver function （ ALT, AST, TBIL, r-GT） , serum lipid levels and the stage of fatty liver （ B-mode uhrasonography）, before and after treatment. Results： There were no significant differences between two groups in the recovery of liver function. The levels of TG and TC were lower after treatment with polyene phosphatidylcholine than with diammonium glycyrrhizinate （P 〈 0.05）. The severity of fatty liver was less in polyene phosphatidylcholine group than in diammonium glycyrrhizinate group. Conclusion： Both diammonium glycyrrhizinate and polyene phosphatidylcholine are effective in treating liver damage of NASH patients. Polyene phosphatidylcholine more effectively improves serum lipid levels and fatty liver severity than diammonium glycyrrhizinate.

关 键 词：非酒精性脂肪性肝炎 甘草酸二铵 多烯磷脂酰胆碱 疗效 

分 类 号：R575.1[医药卫生—消化系统]