4-(2',4'-二氟苯基)-苯乙酮的拜耳-维利格反应研究  

Study on Baeyer Villiger Reaction of 4-Acetyl-(2',4'-difluoro )biphenyl

作　　者：瞿军[1] 陈志荣[2] 王晓冬 

机构地区：[1]江苏省化工研究所,江苏南京210024 [2]浙江大学联合化学反应工程研究所,浙江杭州310027 [3]商丘市进出口商品检验局,河南商丘710049

出　　处：《精细化工》2000年第2期118-120,共3页Fine Chemicals

摘　　要：研究了题示化合物的拜耳－ 维利格反应特性，考察了温度、催化剂、惰性气体保护、操作方式、过酸用量等影响因素。确定了该反应的最佳条件为：５０ ℃，复合催化剂催化，惰性气体保护，两步法操作，ｎ（过酸）∶ｎ（酮）＝ ３∶１。揭示了有无惰性气体保护对该反应的反应速率和收率有重要的影响这一特性，并给出了解释。在最佳条件下，整个反应时间只需７ ｈ，且收率能达到９２ ％ 。The Baeyer Villiger reaction of the title compound was studied.The catalyst,inert gas protection,temperature and ratio of raw materials were inspected.The optimum technological conditions were determined that the reaction took place at 50 ℃ under inert gas protection by two stage operation and molar ratio of peracid/4 acetyl (2',4' difluoro )biphenyl=3/1.Under these conditions,the reaction was finished in about 7-8 h and the yield was about 92%.Especially,the influence of inert gas protection was shown and some explanations were given.

关 键 词：二氟苯基 苯乙酮 拜耳-维利格反应 有机药物 

分 类 号：TQ463.4[化学工程—制药化工]