BIOMIMETIC SURFACE PREPARATION OF INERT POLYMER FILMS VIA GRAFTING LONG MONOALKYL CHAIN PHOSPHATIDYLCHOLINE  

作　　者：李洁华 谭鸿 

机构地区：[1]College of Polymer Science and Engineering,Sichuan Unversity,State key Laboratory of Polymer Materials Engineering, Chengdu 610065,China

出　　处：《Chinese Journal of Polymer Science》2012年第2期190-198,共9页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.20804025 and 50673063);Program for the New-Century Excellent Talents of Ministry of Education of China(NCET-08-0381);Sichuan Provincial Science Fund for Distinguished Young Scholars(09ZQ026-024)

摘　　要：To explore construction of novel mimicking biomembrane on biomaterials surfaces, a new polymerizable phosphatidylcholine containing a long monoalkyl chain ended with acryl group （AASOPC） was designed and synthesized, which was easily derived from the terminal amino group of 9-（2-amino-ethylcarbamoyl）-nonyl-l-phosphatidyl-choline （ASOPC） reacting with acryloyl chloride. The obtained AASOPC was grafted on poly（ethylene terephthalate） （PET） via surface-initiated atom-transfer radical polymerization （SI-ATRP） to form mimicking biomembrane. These modified surface structures of PET were investigated using water contact angle （WAC）, X-ray photoelectron spectroscopy （XPS） and atomic force microscopy （AFM）. The results indicated that the new mimicking phosphatidylcholine biomembrane could be prepared on inert polymer surfaces by using the acryloyl phosphatidylcholine （AASOPC） via surface-initiated atom transfer radical polymerization （SI-ATRP）.To explore construction of novel mimicking biomembrane on biomaterials surfaces, a new polymerizable phosphatidylcholine containing a long monoalkyl chain ended with acryl group （AASOPC） was designed and synthesized, which was easily derived from the terminal amino group of 9-（2-amino-ethylcarbamoyl）-nonyl-l-phosphatidyl-choline （ASOPC） reacting with acryloyl chloride. The obtained AASOPC was grafted on poly（ethylene terephthalate） （PET） via surface-initiated atom-transfer radical polymerization （SI-ATRP） to form mimicking biomembrane. These modified surface structures of PET were investigated using water contact angle （WAC）, X-ray photoelectron spectroscopy （XPS） and atomic force microscopy （AFM）. The results indicated that the new mimicking phosphatidylcholine biomembrane could be prepared on inert polymer surfaces by using the acryloyl phosphatidylcholine （AASOPC） via surface-initiated atom transfer radical polymerization （SI-ATRP）.

关 键 词：PHOSPHATIDYLCHOLINE Mimicking biomembrane SI-ATRP. 

分 类 号：O631.3[理学—高分子化学]