槐耳颗粒对原发性肝癌患者术后长期生存的影响  

Adjuvant huaier on long-term survivals after curative hepatectomy for primary liver cancer

作　　者：阎涛[1] 毕新宇[1] 方仪[1] 周健国[1] 赵建军[1] 黄振[1] 周海涛[1] 李聪[1] 李原[1] 赵平[1] 蔡建强[1] 

机构地区：[1]北京协和医学院中国医学科学院肿瘤医院腹部外科,100021

出　　处：《中华肝胆外科杂志》2012年第2期99-102,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的观察槐耳颗粒对原发性肝癌术后复发转移的影响。方法回顾性分析2002年1月至2006年1月我院外科治疗的175例原发性肝癌患者的临床资料。根据术后是否应用槐耳颗粒分为治疗组（A组，87例，术后加用槐耳颗粒，60g／d，服用时间大于6个月）和对照组（B组，88例，术后未服用槐耳颗粒）。结果全组术后1、3、5年总生存率分别为91．9％、73．9％、56．0％。1、3、5年无复发生存率分别为68．1％、48．4％、40．2％。其中治疗组患者1、3、5年总生存率分别为91．8％、79．3％、65．2％，显著高于对照组的92．0％、68．3％、46．6％（P=0．038）。另外，治疗组患者复发后1、3、5年带瘤生存率为78．6％、46．9％、38．2％，也明显高于对照组的69．0％、16．8％、12．6％（P=0．040）。COX多因素生存分析显示：术后是否服用槐耳颗粒、是否合并肝炎以及肝硬化程度和脉管瘤栓是影响肝癌患者术后总生存率的独立因素（P〈0．05）；围手术期输血以及肿瘤组织学分级是影响无复发生存率的独立因素；术后是否服用槐耳颗粒以及病理类型是影响带瘤生存率的独立因素。结论原发性肝癌根治术后辅助槐耳颗粒治疗可降低肝癌术后复发率，延长复发后生存时间，从而提高原发性肝癌患者的总生存率。Objective To study the effects of adjuvant Huaier on long-term survivals after curative partial hepatectomy for primary liver cancer. Methods 175 patients with primary liver cancer who received curative partial hepatectomy from January 2002 to January 2006 were divided into two groups： the treatment group （group A, n=87） and the control group （group B, n=88）. Group A was treated with Huaier （60 g per day for 6 months） after the operation while group B received no Huaier treatment. Results The overall 1 , 3- and 5-year survival rates and disease free survival rates were 91.9%, 73.9% , and 56.0% and 68.1%, 48.4% and 40.2%, respectively. The overall 1-,3- and 5-year survival rates in group A were significantly higher than group B （91.8%, 79.3%, 65.2%vs 92.0% 68.3%, 46.6%, P=0.038）. In addition, the 1 , 3 and 5-year survival rates after tumor recurrence in group A was also significantly higher than group B （78.6%, 46.9%, 38.2% vs 69.0%, 16.8%, 12.6%, P=0. 040）. Multivariate analysis showed that the use of Huaier, hepatitis infection, severity of cirrhosis, vascular cancer thrombus were the most important prognostic factors for overall long-term survival （P〈0.05）. Blood transfusion and histological grade were independent risk factors for disease free survival. The use of Huaier and the clinicopathological type were significantly co-related to the survival from recurrence/metastasis to death. Conclusion The use of Huaier improved disease free survival and the survival from recurrence or metastasis for patients with primary liver cancer following curative hepatectomy.

关 键 词：原发性肝癌 槐耳颗粒 转移复发 

分 类 号：R735.7[医药卫生—肿瘤]