三阴性乳腺癌的预后与上皮间叶转化的相关性  

Prognosis of Triple-negative Breast Cancer and Its Relevance to Epithelial-mesenchymal Transitions

作　　者：龚益平[1] 漆楚波[2] 王明伟[2] 陈创[3] 赵德绵[1] 许娟[1] 邵军[1] 程洪涛[1] 夏和顺[2] 

机构地区：[1]湖北省肿瘤医院乳腺科,武汉430079 [2]湖北省肿瘤医院病理科,武汉430079 [3]武汉大学中南医院肿瘤科

出　　处：《肿瘤防治研究》2012年第2期173-176,共4页Cancer Research on Prevention and Treatment

基　　金：湖北省自然科学基金资助项目(2009CDB333)

摘　　要：目的探讨三阴性乳腺癌的预后及与上皮间叶转化的关系。方法乳腺癌患者240例,根据ER、PR、Her-2的检测结果分为三组:三阴性组、受体阳性组和Her-2阳性组。原发灶石蜡标本制作组织芯片,免疫组织化学检测Vimentin的表达,比较三组的预后及Vimentin的表达差异。结果三阴性组的总生存及5年生存率均比受体阳性组差,和Her-2阳性组相比,差异无统计学意义。而三阴组的Vimentin阳性表达率明显高于受体阳性组或Her-2阳性组。结论三阴性乳腺癌的预后与上皮间叶转化有关。Objective To investigate the prognosis of triple-negative breast cancer and its relevance to epithelial-mesenchymal transition（EMT）.Methods Two hundred and forty patients of breast cancer were classified into 3 groups,triple-negative group,receptor positive group and Her-2 positive group,according to the expression of estrogen receptor and progesterone receptor as well as Her-2 protein.Paraffin-embedded specimens of the primary tumors were collected and tissue micro-array blocks were constructed.Vimentin expressions were detected by imunohistochemistry.The prognosis and vimentin expression among the 3 groups were analyzed.Results The overall survival and the 5 year survival rate of triple-negative group were significantly decreased compared to receptor positive group,but were not statistically different from those of Her-2 group.Conclusion The poor prognosis of triple-negative breast cancer was associated with EMT.

关 键 词：乳腺肿瘤 预后 上皮间叶转化 波形蛋白 

分 类 号：R737.9[医药卫生—肿瘤]