豆制品与乳腺癌相关性的Meta分析  

Meta Analysis on Relationship between Soyfood and Breast Cancer

作　　者：马骏[1] 聂胜男[1] 史本玲[1] 左文述[1] 

机构地区：[1]山东省肿瘤医院山东省医学科学院乳腺科,济南250117

出　　处：《肿瘤防治研究》2012年第2期218-221,共4页Cancer Research on Prevention and Treatment

摘　　要：目的收集豆制品与乳腺癌发病风险的文献,并对文献进行统计学Meta分析,探讨豆制品摄入与乳腺癌的相关性。方法以"豆制品"和"乳腺肿瘤"等为关键词,检索CHKD期刊全文数据库、中国生物医学文献数据库(CBM)和Pubmed数据库,收集2001—2011年发表的豆制品与乳腺癌发病风险的文献。应用统计学软件对文献数据进行统计分析。结果共14项研究被纳入分析。14项研究存在异质性(Q=15.7,P=0.000),采用随机效应模型进行合并计算,豆制品的合并RR值为0.61,95%CI为0.40～0.82;豆腐的合并RR值为0.77,95%CI为0.69～0.88。合并分析表明,豆制品的摄入可以降低乳腺癌的发病风险。偏倚分析显示,无发表偏倚。结论豆制品是乳腺癌的保护性因素,豆制品的摄入可以有效降低乳腺癌发病风险。Objective To collect literatures about breast neoplasms and soyfood,and detect the relationship between breast neoplasms and soyfood by meta analysis.Methods Using breast neoplasms and soyfood as key words,CHKD,CBM and medline databases were searched,to collect literatures published from 2001 to 2011.And the data of literatures were analyzed by statistics software.Results Totally 14 literatures were involved.There was heterogenicity in the literatures（Q=15.7,P=0.000）.According to random effects model,the pooled RR of soyfood and tofu were 0.73（95%CI：0.58~0.94） and 0.77（95%CI：0.69~0.88） respectively.It showed that soyfood could decrease the risk for breast cancer.ConclusionSoyfood might be protective factors for breast cancer,and decrease the risk of breast cancer through intake.

关 键 词：乳腺肿瘤 植物性雌激素 异黄酮 豆制品 META分析 

分 类 号：R739.9[医药卫生—肿瘤]