郑州市女性HPV感染状况及基因型的分布情况调查  

Investigation of infection and genotype of HPV in Zhengzhou

作　　者：闫琛[1] 杨广英[1] 

机构地区：[1]郑州人民医院,河南郑州450003

出　　处：《中外医学研究》2012年第5期64-66,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的探讨郑州市妇女人乳头瘤病毒(HPV)感染的状况和基因型的分布情况,为宫颈癌防治提供理论依据。方法采用SPR生物传感器对郑州市1192位女性进行HPVDNA分型检测,并对各亚型的感染情况进行统计分析。结果 1192位女性中共检出HPV阳性者309例,阳性率25.9%,46.9%的HPV阳性者年龄20～29岁;高危型占84.0%,以HPV16、HPV58、HPV52和HPV35型为主;低危型占16.0%,以HPV11和HPV6型多见;单一感染为227例,占73.5%;多重感染82例,占26.5%。结论 SPR生物传感器一次检测24种HPV亚型,能判断患者是否为持续感染,对有效防治宫颈癌前病变、降低宫颈癌的发病率有重要意义。Objective To detect and analyze infection and the genotype of human papillomavirus（HPV） in the area of Zhengzhou,and to provide a theory basis for therapy and prevention against cervical cancer.Methods Totally 1192 samples selected from women of Zhengzhou were detected for HPV DNA genotypes by surface plasma resonance（SPR） biosensor.Results The HPV-positive rate was 25.9%（309/1192）,46.9%（145/309）of the HPV-positive women were the women whose age were between 20 and 29.The rate of high-risk HPV and low-risk HPV were 84.0% and 16.0% respectively.The major genotypes of high-risk HPV were HPV16,HPV58,HPV52,and HPV35;and the major genotypes of low-risk HPV were HPV11 and HPV6.The rate of single infection with HPV was 73.5%（227/309）,and the rate of multiple infections was 26.5%（82/309）.Conclusion SPR biosensor can detect 24 HPV subtypes,and it can judge whether the patient is persistent infection or not.So it will play an important role in preventing pre-cancer pathological changes in cervix,and reducing the incidence rate of cervical cancer.

关 键 词：宫颈癌 HPVDNA分型 SPR生物传感器 

分 类 号：R737.33[医药卫生—肿瘤]