DNA序列映射方法对蛋白质编码区预测准确率的影响  

Effects of Mapping Methods on Accuracy of Protein Coding Regions Prediction

作　　者：马玉韬[1,2] 张成[1] 杨泽林[1] 李琦[1] 杨婷[1] 

机构地区：[1]宁夏大学物理电气信息学院,宁夏银川750021 [2]天津大学电子信息工程学院,天津300072

出　　处：《安徽农业科学》2012年第6期3234-3238,共5页Journal of Anhui Agricultural Sciences

基　　金：宁夏自然科学基金(NZ1024);宁夏高校科学研究项目(201027)资助

摘　　要：[目的]探讨当前主要的DNA序列映射方法对蛋白质编码区的预测准确率的影响,寻找有效的映射方法。[方法]以AC(Approxi-mate Correlation)为碱基层的预测准确率的测度,采用FIR(Finite Impulse Response)窄通带滤波器预测算法研究各种映射方法对预测准确率的影响。[结果]在ALLSEQ和HMR195 2个DNA序列集上,Voss法和Z-curve方法是较PN(Paired Numeric)法、EIIP(Electron-IoInteraction Potential)法和复数法更为有效的映射方法。[结论]该研究结果为用预测结果的AC值来验证新映射方法的有效性奠定了基础,对利用生物信息学方法正确揭示DNA序列的结构具有重要意义。[Objective]To discuss the effects of major mapping methods for DNA sequence on the accuracy of protein coding regions prediction,and to find out the effective mapping methods.[Method] By taking Approximate Correlation（AC） as the full measure of the prediction accuracy at nucleotide level,the windowed narrow pass-band filter（WNPBF） based prediction algorithm was applied to study the effects of different mapping methods on prediction accuracy.[Result] In DNA data sets ALLSEQ and HMR195,the Voss and Z-Curve methods are proved to be more effective mapping methods than paired numeric（PN）,Electron-ion Interaction Potential（EIIP） and complex number methods.[Conclusion] This study lays the foundation to verify the effectiveness of new mapping methods by using the predicted AC value,and it is meaningful to reveal DNA structure by using bioinformatics methods.

关 键 词：预测准确率 蛋白质编码区 映射方法 加窗 窄通带滤波器 

分 类 号：Q523[生物学—生物化学]