Effects of cadmium,17 β-estradiol and their interaction in the male Chinese loach (Misgurnus anguillicaudatus)  

作　　者：LÜ XueFei LIU FeiYuan ZHOU XiaoPing ZHOU QunFang DENG YuLin 

机构地区：[1]School of Life Science,Beijing Institute of Technology,Beijing 100081,China [2]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy ofSciences,Beijing 100085,China [3]Beijing Centre for Physical and Chemical Analysis,Beijing 100094,China

出　　处：《Chinese Science Bulletin》2012年第8期858-863,共6页

基　　金：supported by the National Natural Science Foundation of China (20905007);State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (KF2010-09)

摘　　要：To assess the interaction effect between cadmium (Cd) and 17-estradiol (E2),male Chinese loaches (Misgurnus anguillicaudatus) were exposed to E2 (1 g/L) and Cd (50 or 500 g/L) alone and in combination using a semi-static waterborne exposure system.The effects of E2 on the accumulation and distribution of Cd,as well as the effects of Cd on vitellogenin (Vtg) synthesis induced by E2,were investigated.Cd mainly accumulated in the kidneys,liver,intestines,and gills,with little amounts in muscles,bones,and gonads.Co-exposure with E2 did not change the main targets for Cd.E2 could induce Vtg synthesis in male Chinese loaches,and co-exposure with 50 or 500 g/L Cd could inhibit the Vtg induced by 1 g/L E2.Compared with the results reported in the literature,it can be concluded that factors such as fish species,Cd dosage,and manner of exposure might make contributions to the interaction between Cd and E2.Our results also suggested that male Chinese loaches are susceptible to Cd,and can be recommended as a potential sentinel species to study the ecotoxicology of heavy metals.To assess the interaction effect between cadmium （Cd） and 17flestradiol （E2）, male Chinese loaches （Misgurnus anguillicauda tus） were exposed to E2 （1 ktg/L） and Cd （50 or 500 ~g/L） alone and in combination using a semistatic waterborne exposure sys tem. The effects of E2 on the accumulation and distribution of Cd, as well as the effects of Cd on vitellogenin （Vtg） synthesis induced by E2, were investigated. Cd mainly accumulated in the kidneys, liver, intestines, and gills, with little amounts in muscles, bones, and gonads. Coexposure with E2 did not change the main targets for Cd. E2 could induce Vtg synthesis in male Chinese loaches, and coexposure with 50 or 500 ~tg/L Cd could inhibit the Vtg induced by 1 ~tg/L E2. Compared with the results reported in the literature, it can be concluded that factors such as fish species, Cd dosage, and manner of exposure might make contribu tions to the interaction between Cd and E2. Our results also suggested that male Chinese loaches are susceptible to Cd, and can be recommended as a potential sentinel species to study the ecotoxicology of heavy metals.

关 键 词：镉(CD) 泥鳅 中国 雌二醇 卵黄蛋白原 生态毒理学 互动效应 曝光系统 

分 类 号：X171[环境科学与工程—环境科学] S966.4[农业科学—水产养殖]