脑白质疏松症患者认知功能水平与脑血流动力学的关系  

Relationship between the cognitive function level and cerebral hemodynamics in patients with leukoaraiosis

作　　者：张英丽[1] 吉中国[1] 张英瑞[2] 

机构地区：[1]山东大学附属省立医院保健神经科,济南250021 [2]聊城市人民医院神经内科监护室,山东聊城252000

出　　处：《山东大学学报（医学版）》2012年第2期57-59,63,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨脑白质疏松症(LA)患者认知功能水平与脑血流动力学的关系。方法对90例LA患者进行颅脑MRI、神经心理学与TCD检查,根据评分将其分为3组:无认知功能障碍组、轻度认知功能障碍组和痴呆组。运用方差分析及相关分析来研究LA患者不同认知功能水平与大脑中动脉(MCA)搏动指数(PI)、平均血流速度(Vm)的关系。结果 PI在无认知功能障碍组、轻度认知功能障碍组和痴呆组之间差异具有统计学意义(P<0.05),且PI与LA患者的认知功能水平为正相关关系(r=0.688,P<0.01)。Vm在三组患者之间差异无统计学意义(P>0.05)。结论 LA患者认知功能水平与大脑中动脉PI有关,PI值越大,LA患者认知功能障碍程度越重。LA患者的认知功能水平与大脑中动脉Vm无明显相关关系。Objective To investigate the relationship between the cognitive function level and cerebral hemodynamics in patients with leukoaraiosis. Methods Ninety patients with LA were subjected to cerebral MRI, neuropsychological and TCD examinations. On the basis of neuropsychological scoring these patients were divided into three groups： without cognitive dysfunction, mild cognitive impairment and dementia. The pulsatility index （PI） and mean blood flow velocity （Vm） of the middle cerebral artery （MCA） were studied using variance analysis and correlation analysis. Results PI Differences among the three groups were significant （ P 〈 0.05 ）, and there was a positive correlation between PI and cognitive function level （r =0. 688 ,P 〈0.01 ）. By contrast, Vm differences among the three groups were not significant （ P 〉 0.05 ）. Conclusion The level of cognitive function in LA patients and their PI are related, and the greater the PI, the more severe the cognitive impairment. On the other hand, the level of cognitive function in LA patients was not correlated with the Vm values.

关 键 词：脑白质疏松症 认知功能 经颅多普勒 平均脑血流速度 搏动指数 

分 类 号：R743.9[医药卫生—神经病学与精神病学]