Tiam1和MTA1在喉鳞癌组织中的表达及意义  

Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma

作　　者：吴桂卿[1] 田军[2] 孙静[1] 陈琪[1] 

机构地区：[1]潍坊医学院耳鼻喉科教研室,山东潍坊261053 [2]潍坊市人民医院耳鼻喉科,山东潍坊261041

出　　处：《山东大学耳鼻喉眼学报》2012年第1期41-43,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的探讨Tiam1和MTA1在喉鳞癌组织中的表达及其与临床病理特征的关系。方法采用免疫组化方法检测46例喉鳞癌组织及10例癌旁正常组织中Tiam1和MTA1的表达。结果 Tiam1和MTA1在喉鳞癌组织中的表达明显高于癌旁正常组织(P<0.01)。在喉癌组织中Tiam1的表达与肿瘤的临床分期及有无淋巴结转移有关,而与患者的年龄、性别及肿瘤的病理分级无关。MTA1的表达与肿瘤的临床分期、病理分级及有无淋巴结转移有关,而与患者的年龄、性别无关。喉癌组织中Tiaml蛋白与MTA1蛋白的表达呈正相关。结论Tiam1和MTA1可能与喉鳞癌的侵袭、转移相关,对喉癌的诊断、治疗和预后具有重要参考意义。Objective To observe expression of Tiam1 and MTA1 in human laryngeal squamous cell carcinoma and its relationships to clinical-pathological features.Methods Expression of Tiam1 and MTA1 in 46 human laryngeal squamous cell carcinomas（group A） and 10 tumor-adjacent normal larynx tissues（group B） were detected by immunohistochemistry.Results Expression of Tiam1 and MTA1 was higher in group A than that in group B（P0.01）.Expression of Tiam1 was correlated with clinical staging,lymph node metastasis,but not age,sex or pathologic stage.Expression of MTA1 was correlated with clinical staging,lymph node metastasis and pathological stage,but not age or sex.Expression of Tiam1 was positively correlated to that of MTA1 in group A.Conclusions Tiam1 and MTA1 may be correlated with invasion and metastasis of laryngeal carcinoma,and it is useful for diagnosis,treatment and prognosis.

关 键 词：喉鳞状细胞癌 TIAM1 MTA1 免疫组化 

分 类 号：R739.65[医药卫生—肿瘤]