鼠三叉神经节中神经肽阳性胞体的分布与密度  

The distributions and densities of neuropeptides like immunoreactive neurons in the trigeminal ganglions of rats.

作　　者：刘向辉[1] 斯方杰[2] 徐正林[1] 饶志仁 

机构地区：[1]解放军81医院,南京210002 [2]第四军医大学口腔医学院

出　　处：《临床口腔医学杂志》2000年第1期5-7,共3页Journal of Clinical Stomatology

摘　　要：目的　观察鼠三叉神经节中神经肽P物质、降钙素基因相关肽及神经肽Y阳性神经元的分布与密度,为今后研究神经肽在口腔颌面部的作用提供形态学依据。方法　SD雄性大白鼠8只,灌注固定,取双侧三叉神经节水平位连续切片,ABC法漂染,镜检,计算机图像分析。结果　三叉神经节中有丰富而均匀分布的P物质及降钙素基因相关肽阳性胞体,分别占神经元总数的15%和40%左右,染色深浅不一,主要为中小型假单极细胞,其阳性纤维聚集成束,远心端加入上、下颌神经及眼神经,近心端通向中枢神系统,但三叉神经节中无神经肽Y阳性胞体,只有散在阳性纤维分布。结论　三叉神经节中有丰富的P物质和降钙素基因相关肽神经元,但无神经肽Y神经元。Objective To observe the distributions and densities of substance (PSP) calcitonin gene related peptide (CGRP)and neuropeptide NPY like immunoreactive ( LI) neurons in the rat trigeminal ganglions (TrG) and provide morphologic basis ofr further studying the roles of neuropeptides in the oral and maxillofacial area. Methods The avidin biotin peroxidase complex method and imagine analysis were employed to detect neuro peptides LI neurons in trigeminal ganglions of eight SD male rats. Results Substance P and calcitonin gene related peptide LI neurons were plentifully located in rat trigeminal ganglions. They accounted for 15% and 40% of all neurons respectively and were middle to small sized pseudounipolar cells mainly. Their immunoreactive fibres gathered and joined ophthalimic, maxillary and mandibular nerve. There were not any neuropeptide Y LI cell bodys but a few of neuropeptide Y LI fibres. Conclusion There are plentiful substance P and calcitonin gene related peptide LI neurons but no neuropeptide Y LI neurons in the rat trigeminal ganglions.

关 键 词：P物质 神经肽Y 三叉神经节 CGRP 口腔颌面部 

分 类 号：R782.02[医药卫生—口腔医学]