慢性粒细胞性白血病急变期的细胞遗传学研究  

Cytogenetic study of CML at blast crisis

作　　者：蔡莹[1] 孟德润[1] 王孟学[1] 刘权章[2] 

机构地区：[1]哈尔滨医科大学附属第二医院血液病研究所 [2]哈尔滨医科大学遗传学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2000年第1期36-38,共3页Journal of Harbin Medical University

摘　　要：目的　探讨白血病患者细胞遗传学改变和预后关系。方法　通过短期培养法和直接法对 3 0例慢性粒细胞白血病急变期患者的骨髓有核细胞进行染色分析。结果　 3 0例病人Ph染色体均为阳性 ,同时 2 8例出现了染色体数目异常。结论　出现额外染色体畸变时 ,提示临床治疗效果差 ,预后不良 ,生存期短 ,易急变。慢粒急变时 。Objective To study the relationship beween cytogenetic change and the prognosin in patients with CML acute nonlymphoblastic leukemia.Methods The karyotype analysis of nuclear cells of bone marrow in 30 cases at acute stage were performed by short culture and direct preparation.Results 30 cases were positive with Ph chromosome,meantime 28 cases had chromosome number abnormality.Conclusion When patients with CML have other chromosome abnormalities at the chronic stage,It suggest patients with CML are at acute stage.These cytogenetic abnormalities happened in chronic stage showed the worst prognosis.

关 键 词：白血病 染色体 慢性 急变期 粒细胞性 

分 类 号：R733.72[医药卫生—肿瘤]