早产低体重儿与母亲唾液中牙周致病菌的关系  

Relationship between the preterm low birth weight infant and the periodontal pathogen bacteria in maternal saliva

作　　者：陈智滨[1] 和璐[1] 康军[1] 黄振[1] 沙月琴[1] 朱万孚[2] 闫玲[2] 

机构地区：[1]北京大学口腔医学院·口腔医院牙周科,北京100081 [2]北京大学基础医学院病原生物学系,北京100191

出　　处：《北京大学学报（医学版）》2012年第1期29-33,共5页Journal of Peking University:Health Sciences

基　　金：国家自然科学基金资助(30572032)~~

摘　　要：目的:分析早产低体重儿(preterm low birth weight,PLBW)母亲唾液中主要牙周致病菌,即牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)、福赛坦氏菌(Tannerella forsythia,Tf)、齿垢密螺旋体(Treponema denticola,Td)检出水平及母亲牙周临床状况,探讨母亲牙周炎致病菌与早产低体重儿发生的关系。方法:选取北京4所医院产后1～1.5年的母亲110人,PLBW组母亲72人,21～39岁,正常出生体重组(normal birth weight,NBW)母亲38人,23～38岁。收集唾液样本,记录探诊深度(probing depth,PD)、菌斑指数(plaque index,PLI)、出血指数(bleeding in-dex,BI)及临床附着丧失(clinical attachment loss,CAL)。用PCR方法检测唾液中的Pg、Tf、Td;根据Pg、Tf、Td检出与否分为Pg、Tf、Td阳性和阴性组。结果:(1)PLBW组和NBW组牙周临床指标及Pg、Tf、Td检出率:PLBW组和NBW组CAL分别为0.18(0.00,4.97)mm、0.08(0.00,1.81)mm,两组间差异有统计学意义(P<0.05);Pg检出率分别为94.4%和78.9%,两组间差异有统计学意义(P<0.05);Tf检出率分别为84.7%和94.7%,Td检出率分别为86.1%和89.5%,两组间差异均无统计学意义。(2)Pg、Tf和Td阳性组与阴性组间牙周临床指标、新生儿体重及孕周:Pg阳性组与阴性组间CAL[2.25(0.54,4.00)mm、1.44(0.63,3.80)mm]、PD[(2.47±0.43)mm、(1.94±0.39)mm]、PLI(1.80±0.44、1.36±0.34)、新生儿体重[(2 482.95±813.17)g、(3 425.00±1 024.36)g]差异均有统计学意义(P<0.05);Tf阳性组与阴性组间CAL[0.14(0.00,4.9)mm、0.03(0.00,0.44)mm]、PD[(2.44±0.46)mm、(2.17±0.38)mm]差异有统计学意义(P<0.05);Td阳性组和阴性组间PD[(2.44±0.46)mm、(2.14±0.43)mm]和BI(2.31±0.86、1.83±0.68)差异有统计学意义(P<0.05)。结论:Pg、Tf和Td在两组母亲唾液中检出水平较高,Pg可能与低体重儿发生有关。Objective： To investigate the possible relationship between the preterm and/or low birth weight（PLBW） and three anaerobic microorganisms in saliva of their mothers,including Porphyromonas gingivalis（Pg）,Tannerella forsythia（Tf）,Treponema Denticola（Td）.Methods： 110 retrospective cases were collected from 4 hospitals in Beijing urban and suburban areas.PLBW group included 72 subjects and NBW group included 38 subjects.They were made up of 2∶1 matched data.Nonstimulated saliva samples were collected from all the individuals.The periodontal examinations included plaque index（PLI）,probing depth（PD）,bleeding index（BI）,and clinical attachment loss（CAL） were performed in 1-1.5 years after preterm.According to the PCR results in their saliva,they were divided into positive group and negative group of Pg,Tf,Td.Results： CAL in PLBW and NBW groups were 0.18（0.00,4.97） mm and 0.08（0.00,1.81） mm respectively which was significantly different（P0.05）.The detection rates of Pg in PLBW and NBW groups were 94.4% and 78.9% respectively（P0.05）.The detection rates of Tf were 84.7% and 94.7% respectively（P0.05）.The detection rates of Td were 86.1% and 89.5% respectively（P0.05）.The clinical parameters of CAL [2.25（0.54,4.00） mm,1.44（0.63,3.80） mm],PD[（2.47±0.43） mm,（1.94±0.39） mm],PLI（1.80±0.44,1.36±0.34） in Pg positive group was significantly higher than those in Pg negative group.The birth weight of Pg positive group [（2 482.95±813.17） g] was significantly lower than Pg negative group [（3 425.00±1 024.36） g].CAL [0.14（0.00,4.9） mm,0.03（0.00,0.44） mm],PD[（2.44±0.46） mm,（2.17±0.38） mm] were significantly different between Tf positive and negative group.PD [（2.44±0.46） mm,（2.14±0.43） mm] and BI（2.31±0.86,1.83±0.68） were significantly different between Td positive and negative group.Conclusion： There is higher level of Pg,Tf and Td in the saliva of both PLBW and NBW groups.The detection of Pg may be related

关 键 词：牙周炎 孕妇 婴儿 出生时低体重 唾液 细菌 

分 类 号：R781.42[医药卫生—口腔医学]