microRNAs在肿瘤表观遗传调控的研究进展  

Advances in the Research on the MicroRNAs Related to Tumorous Epigenetic Modifications

作　　者：马筱秋[1] 蔡建春[1] 

机构地区：[1]厦门大学医学院,厦门大学附属第一医院肿瘤外科,厦门市肿瘤中心

出　　处：《中国肿瘤临床》2012年第4期237-240,共4页Chinese Journal of Clinical Oncology

基　　金：福建省自然科学基金面上项目基金(编号:2009D004)资助~~

摘　　要：microRNAs和表观遗传修饰都在肿瘤的发生发展过程中发挥重要作用研究发现microRNAs与表观遗传之间存在复杂的调控关系,主要通过DNA甲基化和组蛋白修饰等方式与microRNAs进行相互调节,这为肿瘤的机制研究提供了新的方向。利用表观遗传的可逆性调节相关microRNAs的表达可抑制肿瘤生长,在肿瘤治疗方面显示出巨大潜力。Both microRNA （ miRNA ） and epigenetic modifications play crucial roles in tumorigenesis and tumor progression. Scientific findings have revealed that microRNA and epigenetics are intertwined. The mutual interaction between epigenetics and microRNA is carried out mainly through DNA methylation and histone modification, which provides a new orientation for studies on the pathogenesis of tumors. Tumors could be inhibited through the reversible nature of epigenetics to regulate the expression of tumor-related microRNA. These results show great potential in tumor therapy. The present review provides a comprehensive overview of the current literature on microRNA related to tumorous epigenetic modifications.

关 键 词：microRNA表观遗传学肿瘤 治疗 

分 类 号：R730.2[医药卫生—肿瘤]