丁二酸洛沙平治疗精神分裂症对照研究的Meta分析  

Meta-analysis of comparative study on Loxapine succinate in the treatment of schizophrenia

作　　者：阳中明[1] 周恒[1] 

机构地区：[1]安徽省芜湖市第四人民医院,安徽芜湖241002

出　　处：《中国民康医学》2012年第3期281-282,共2页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨丁二酸洛沙平治疗精神分裂症的疗效。方法:应用Meta分析对6项研究丁二酸洛沙平与其它抗精神病药治疗精神分裂症对照研究的文献进行再分析,评价其合并效应量的大小和综合显著性检验。结果:丁二酸洛沙平治疗前后的自身对照,合并效应量d=2.80,95%CI为(2.55,3.05),综合显著性检验x2=21.93,P<0.01,提示丁二酸洛沙平治疗精神分裂症前后症状学变化有非常显著性差异,效应极强。丁二酸洛沙平与对照药在第2周末和治疗后组间的比较,提示丁二酸洛沙平与对照药疗效相当,没有显著性差异。结论:丁二酸洛沙平与对照药的疗效无显著性差异。Objective：To explore the efficacy of Loxapine succinate in the treatment of schizophrenia.Methods：6 comparative studies of Loxapine succinate and the other antipsychotics in the treatment of schizophrenia were analyzed by meta-analysis in therapeutic effects and side effects.Results： The significant difference in change of symptom before and after treatment by Loxapine succinate was found,d=2.80,95% CI（2.55,3.05）,x2=21.93,P0.01.Comparison between Loxapine succinate and the other antipsychotics at 2 weeks treatment and at the end of each trial showed that there was no significant difference with respect to the clinical efficacy.Conclusions： Loxapine succinate has a similar clinical efficacy compared with controlled antipsychotics.

关 键 词：丁二酸洛沙平 精神分裂症 META分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]