草酸艾司西酞普兰对抑郁症患者事件相关电位P300的影响  

Effect of escitalopram on cognitive function P300 in depressive disorders

作　　者：贺文[1] 唐步春[1] 

机构地区：[1]南京医科大学附属无锡精神卫生中心普通精神科,214151

出　　处：《临床精神医学杂志》2012年第1期12-14,共3页Journal of Clinical Psychiatry

基　　金：江苏省卫生厅医学科研面上项目课题(H201043)

摘　　要：目的:探讨草酸艾司西酞普兰对抑郁症患者的事件相关电位P300影响。方法:随机将年龄在18～65岁之间符合中国精神障碍分类与诊断标准第3版抑郁症诊断标准患者30例作为研究组,选择30例性别年龄健康者作为对照组。研究组予草酸艾司西酞普兰治疗。两组分别予听觉P300检测,比较P300潜伏期及波幅的差异。结果:研究组Fz、Pz点潜伏期分别为(319±23)ms、(315±20)ms均比对照组分别为(300±22)ms、(299±21)ms延长,研究组Fz、Cz、Pz点分别为(2.5±1.8)μV、(2.6±2.4)μV、(2.5±3.3)μV波幅均比对照组分别为(3.8±2.0)μV、(3.7±1.9)μV、(4.1±3.0)μV降低(P<0.05或P<0.01)。治疗8周后,研究组Fz、Pz点潜伏期分别为(301±19)ms、(305±19)ms]明显缩短,Fz、Cz、Pz点分别为(3.5±1.8)μV、(3.7±2.1)μV、(3.6±3.5)μV波幅明显升高(P<0.05)。结论:抑郁症患者存在P300异常,草酸艾司西酞普兰具有改善这种异常现象的作用。Objective： To investigate effect of escitalopram on cognitive function P300 in depressive disorders. Method ：30 patients （among 18 -65 years old） met with chinese classification of mental disorders-3 for deprerssive disorders criteria were recruited as research group. 30 matched sex and age healthy adolescents were selected as normal control group. Research group were treated with escitalopram for 8 weeks. All groups were measured with auditory evoked event-related potential P300. P300 latencies and amplitudes of all groups were compared respectively. Results ： Fz, Pz latencies prolonged and the amplitudes of Fz, Cz and Pz site shortened in research group compared with normal control group （ P 〈 0.05 or P 〈 0. 01 ）. After 8 week treatment, Fz, Pz latencies shortened and the amplitudes of Fz, Cz and Pz site rised in research group （P 〈 0.05 ）. Conclusion： Depressive patients presents impaired cognitive function measured with event-related potential P300. Escitalopram can improve cognitive impairment in depressive disorders.

关 键 词：草酸艾司西酞普兰 抑郁症 事件相关电位P300 认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]