壳聚糖、磷脂酰胆碱对轻度认知功能障碍患者脑组织氢质子磁共振波谱成像的影响  

Influence of chitosan and phosphatidylcholine on proton MR spectroscopic imaging of brain tissue in patients with mild cognitive impairment

作　　者：刘利静[1] 李丽新[1] 孟庆慧[2] 龙金凤[3] 

机构地区：[1]潍坊医学院附属医院影像中心,261031 [2]潍坊医学院护理学院 [3]潍坊医学院影像学系

出　　处：《临床神经病学杂志》2012年第1期11-13,共3页Journal of Clinical Neurology

基　　金：山东省自然科学基金资助项目(Y2008C125);山东省教育厅科技计划项目(J08LH67)

摘　　要：目的观察壳聚糖、磷脂酰胆碱对轻度认知功能障碍(MCI)患者海马氢质子磁共振波谱成像(1H-MRSI)的影响。方法对15例MCI患者(MCI组)和15名正常老年人(正常对照组)进行海马1H-MRSI检查。给予MCI组患者壳聚糖、磷脂酰胆碱治疗2个月后对其进行复查,比较N-乙酰天门冬氨酸(NAA)/肌酸(Cr)、胆碱(Cho)/Cr、肌醇(mI)/Cr的比值。结果与正常对照组相比,MCI组服药前、后NAA/Cr比值显著降低,mI/Cr比值显著升高(均P<0.05),Cho/Cr的差异无统计学意义。MCI组治疗后的NAA/Cr比值较治疗前明显升高(P<0.05),mI/Cr比值明显降低(P<0.05),Cho/Cr比值治疗前后的差异无统计学意义。结论1H-MRSI显示,壳聚糖和磷脂酰胆碱能改善脑组织的代谢,可能对MCI有一定的治疗作用。Objective To observe the influence of chitosan and phosphatidylcholine on proton MR spectroscopis imaging （^1H-MRSI） of brain tissue in patients with mild cognitive impairment （MCI）. Methods IH-MRSI of hippocampus was performed in the 15 MCI patients （MCI group） and 15 normal olders （NC group）. The MCI group rechecked after 2 months of therapy with chitosan and phosphatidylcholine. And the ratios of N-acetyl aspartate （NAA）/creatine （Cr）, choline （Cho）/Cr and myo-inositol （mI）/Cr were compared. Results Compared with NC group, the ratios of NAA/Cr in MCI group at pre and post therapy were significantly lower （ all P 〈 0.05 ） , the ratios of ml/Cr were significantly higher （ all P 〈 0. 05 ） , and there was no statical difference in the ratio of Cho/Cr between them. The ratio of NAA/Cr of post therapy in MCI group was significantly higher than pre therapy （ P 〈 0.05 ）, the ratio of ml/Cr was significantly lower （ P 〈 0.05 ）, and there was no statistical difference in the ratio of Cho/Cr between pre and post therapy. Conclusion ^1H-MRSIshows that ehitosan and phosphatidylcholine can improve the metabolism of brain tissue and maybe useful for MCI.

关 键 词：轻度认知功能障碍 海马 氢质子磁共振波谱成像 壳聚糖 磷脂酰胆碱 

分 类 号：R749.1[医药卫生—神经病学与精神病学]