中药组方对黄曲霉毒素B1中毒雏鸭肝功能的影响  

Effects of Traditional Chinese Medicine on Liver Function in Poisoning Ducklings Induced by Aflatoxin B1

作　　者：石达友[1] 廖申权[2] 林远超[1] 李鹏飞[1] 刘念[1] 郭铭生[1] 唐兆新[1] 

机构地区：[1]华南农业大学兽医学院,广东广州510642 [2]广东省农科院兽医研究所,广东广州510640

出　　处：《动物医学进展》2012年第2期31-34,共4页Progress In Veterinary Medicine

基　　金：广东省农业攻关项目(2008B20700004)

摘　　要：为观察黄曲霉毒素B1(AFB1)对试验雏鸭肝功能血清指标的影响及复方中药对AFB1的颉颃效应,本试验选用7日龄健康雏鸭90只,分为3组,每组30只。Ⅰ组为空白对照组,灌胃与试验组等体积二甲基亚砜;Ⅱ组、Ⅲ组为试验组。每天分别按0.1mg/kg剂量给Ⅱ组、Ⅲ组雏鸭灌胃AFB1一次,连续投药21d,试验期间给Ⅲ组雏鸭日粮中添加2%复方中药。分别在给雏鸭投药后7、14、21d,检测雏鸭肝功能部分血清指标。结果显示,Ⅱ组、Ⅲ组雏鸭丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)与Y-谷氨酰转肽酶(GGT)活性显著高于Ⅰ组(P<0.05),而血清总蛋白(TP)与白蛋白(ALB)含量显著下降(P<0.05);与Ⅱ组比较,在日粮中添加复方中药的Ⅲ组雏鸭各项血清指标均有显著改善(P<0.05)。说明黄曲霉毒素B1导致雏鸭肝功能发生显著的变化,而复方中药能明显改善其变化。In order to observe the effects of aflatoxin B1（AFB1） on liver function serum indicators in ducklings and study the antagonistic effect of compound traditional Chinese medicine（TCM） on AFB1,seven day-old ducklings were used as experimental animals.All animals were divided into three groups（30 animals each）.The ducklings in groupⅠwas only administered in the same volume of DMSO as control.The ducklings in group Ⅱ,Ⅲ were administered intragastrically in AFB1 at a dose 0.1 mg/kg body weight respectively,and group III was fed on mixed diet added in 2% TCM.All treatments were given once daily during 7-28 day-old.The ducklings＇ liver function serum indicators were detected on 7th,14th,21th day after treatment.The results showed that the activity of serum alanine amino transferase（ALT）,aspartate amino transferase（AST） and γ-glutamyl transpeptidase（GGT） significantly increased in ducklings of group Ⅱ,Ⅲ compared with groupⅠ（P〈0.05）,and the level of serum total protein（TP） and albumin（ALB） significantly decreased（P〈0.05）.It showed a significant improvements in ducklings liver function serum indicators of TCM treated group Ⅲ compared with groupⅡ（P〈0.05）.The results revealed that TCM could ameliorate the ducklings liver function changes induced by aflatoxin B1.

关 键 词：黄曲霉毒素B1 肝功能 雏鸭 复方中药 

分 类 号：S856.9[农业科学—临床兽医学]