肝硬化患者血浆PGI_2和TXA_2含量变化的临床意义  

The Clinical Value of Changes of Plasma Prostacyclin and Thromboxane A_2 in Patients with Liver Cirrhosis

作　　者：杨晋辉[1] 郑盛 尤丽英[1] 唐映梅[1] 刘海 

机构地区：[1]昆明医学院第二附属医院肝胆胰内科,650000 [2]云南省第三人民医院消化内科,650011

出　　处：《放射免疫学杂志》2012年第1期5-7,共3页Journal of Radioimmanology

摘　　要：目的:观察肝硬化患者血浆中前列环素(PGI_2)和血栓素A_2(TXA_2)含量的变化,探讨其在肝病发生、发展中的临床意义。方法:选取2010年10月～2011年10月间云南省第三人民医院消化内科收治的肝硬化患者48例及健康体检正常者30例,采用放射免疫分析(RIA)分别测定其血浆中PGI_2和TXA_2的代谢产物6-酮-前列环素(6-Keto-PGF_(1α))和血栓素B_2(TXB_2)的含量,进行统计学分析。结果:Child-Pugh分级A级患者血浆中6-Keto-PGF_(1α)和TXB_2含量分别为(108.8±34.2)ng/L和(87.5±19.3)ng/L,B级为(139.4±38.3)ng/L和(106.6±20.7)ng/L,C级为(181.9±53.2)ng/L和(128.5±26.3)ng/L,正常对照组为(90.6±23.6)ng/L和(73.6±18.3)ng/L,经方差分析,各组之间差异有统计学意义(F值分别为5.12,4.63,P均<0.01);各组间经SNK-q检验比较,差异均有统计学意义(P均<0.01);血浆中6-Keto-PGF_(1α)和TXB_2含量在Child-Pugh分级A、B、C级患者中逐级增高。结论:血浆PGI_2和TXA_2参与了肝硬化的发生、发展,动态监测PGI_2和TXA_2含量的变化有利于肝硬化患者病情的判断。Objeotive To evaluate the Changes of plasma prostacyclin （PGI2） and thromboxane A2 （TXA2 ） levels in patients with liver cirrhosis, and to explore its clinical signifieance of occurrence and development in patients with liver disease. Methods 48 cirrhosis patients and 30 healthy people admitted to department of gastroenterology at Yunnan third people＇s hospital from October, 2010 to october, 2011 were admitted to this study. Plasma 6-Keto-prostacyelin （6-Keto-PGF1a） and thromboxane B2 （TXB2 ） were measured by radioimmunoassay （RIA）. Flosults Plasma 6-Keto-PGF1a and TXB2 levels in Child-Pugh grade A patients were （ 108.8 ± 34.2）ng/L and （87.5 ± 19.3）ng/L while those in B grade were （139.4 ± 38.3 ）ng/L and （106.6 ± 20.7 ）ng/L and those in C grade were （ 181.9 ± 53.2） ng/L and （ 128.5 ± 26.3 ） ng/L. These indicators in the eontrol group were （90.6 ± 23.6） ng/L and （73. 6 ± 18.3 ） ng/L. Differences among the groups were statistically significant by analysis of variance （ F values were 5.12,4.63, P 〈 0. 01 ） and the difference was statistically significant between each group by SNK-q test （P 〈0.01 ）. Plasma 6-Keto-PGF1a and TXB2 levels progressively inereased in Child-Pugh classification A, B, C grade patients. Conclusion Plasma PGI2 and TXA2 might participate in the incidence and development of liver cirrhosis. Dynamic monitoring of changes of PGI2 and TXA2 levels were helpful to determine the severity of patients with liver cirrhosis.

关 键 词：肝硬化 前列环素 血栓素A2 

分 类 号：R575.2[医药卫生—消化系统]