血浆和肽素浓度与脑梗死预后的相关性分析  

Correlative Analysis on Plasma Copeptin Concentrations for Predicting the Prognosis of the Patients with Cerebral Infarction

作　　者：李剑[1] 朱颖[1] 吴琦[1] 

机构地区：[1]杭州市上城区中西医结合医院,310008

出　　处：《放射免疫学杂志》2012年第1期80-81,共2页Journal of Radioimmanology

摘　　要：目的:揭示脑梗死患者血浆和肽素浓度,分析其与预后的相关性。方法:对102例健康体检者和102例脑梗死患者,用ELISA检测血浆和肽素浓度,统计分析其水平改变及与预后的相关性。结果:脑梗死患者血浆和肽素浓度(448.1±158.4)pg/ml较健康体检者(57.7±20.6)pg/ml显著升高(P<0.01),与入院时美国国立卫生院神经功能缺损评分显著正相关(P<0.01),是脑梗死1年内预后不良(OR=1.216,95%CI=1.109～1.456,P<0.01)和死亡(OR=1.437,95%CI=1.274～1.783,P<0.01)的独立危险因素,可显著预测脑梗死1年内预后不良(曲线下面积=0.879,95%CI=0.849～0.924,P<0.01)和死亡(曲线下面积=0.884,95%CI=0.854～0.937,P<0.01)。结论:脑梗死后血浆和肽素含量显著升高,临床检测这些指标有助于早期判断脑梗死预后。Objective This study aimed to determine the levels of the plasma copeptin in patients with cerebral infarction and to analyse the correlativity with outcome and prediction of the disease. Methods 102 healthy controls and 102 patients with cerebral infarction were included. Concentrations of the plasma copeptin were measured with ELISA. Its association with disease outcome was analyzed statistically. Results The plasma copeptin levels （448.1 ± 158.4） pg/ml in the patients were significantly higher than those （57.7± 20.6） pg/ml in the healthy controls （ P 〈 0.01 ）, were highly associated with NIHSS score （ t = 10.219, P 〈 0.01 ）, was an independent variable predicting the poor functional outcome（ OR = 1. 216, 95% CI = 1. 109 ~ 1. 456, P 〈 0.01 ） and mortality（ OR = 1. 437, 95% CI = 1. 274 - 1. 783, P 〈 0.01 ） 1 year after cerebral infarction and predicted the poor functional outcome （ Area under curve = 0.879, 95% CI = 0. 849 ~ 0.924, P 〈 0.01 ） and mortality （ Area under curve = 0.884, 95% CI = 0. 854 - 0.937, P 〈 0.01 ） obviously. Conclusion Plasma copeptin levels increasingly apparent after cerebral infarction. Its plasma level can be served as a useful clinical marker for evaluating the prognosis of cerebral infarction.

关 键 词：和肽素 脑梗死 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]