血清丙氨酸氨基转移酶和总胆汁酸联合测定对肝病的诊断价值  

Evaluation of alanine aminotransferase and total bile acids in serum as liver diseases diseases diagnosis

作　　者：王凤学[1] 李树仁[1] 欧阳旭红[1] 

机构地区：[1]遵义医学院附属医院,563003

出　　处：《贵州医药》2000年第3期134-135,共2页Guizhou Medical Journal

摘　　要：目的　评价联合测定血清丙氨酸氨基转移酶（ＡＬＴ）和总胆汁酸（ＴＢＡ）对肝病的诊断价值。方法　临床确诊肝病分成急性黄疸型肝炎、急性无黄疸型肝炎、慢性肝炎、重症肝炎、淤胆型肝炎和肝硬变６组，同时设正常对照组，用紫外酶偶联连续监测法测定血清ＡＬＴ，用酶偶联ＢＮＴ法测定血清ＴＢＡ。结果各组肝病ＡＬＴ和ＴＢＡ检测结果与正常对照组比较：ｔ＞４．２９２，Ｐ＜０．００１。阳性率分别为１００％，８５．９％，６４．６％，１００％，１００％，４０．６％和１００％，８９．１％，７５．９％，１００％，１００％，１００％。联合检测ＡＬＴ和ＴＢＡ对急性无疸型肝炎的阳性率为９５．３％，慢性肝炎的阳性率为８５．５％。结论ＡＬＴ和ＴＢＡ对急性黄疸型肝炎、重症肝炎和淤胆型肝炎具有很高的敏感性，但对急性无黄疸型肝炎、慢性肝炎敏感性较低，但阳性率具有互补性；ＴＢＡ对肝硬变的敏感性优于ＡＬＴ。因此联合检测ＡＬＴ和ＴＢＡ，可提高各种肝病的检出率，有利于临床对肝病的早期诊断和治疗。Objectivev To evaluate diagnostic value of alanine aminotransfrase (ALT) and total bile acids (TBA) in serum to liver diseases. Methods 324 cases from Acute icteric hepatitis (AIH), Acute anicteric hepati- tis (AAH), Chronic hepatitis (CH), Serious hepatitis (SH), Bile foul hepatitis (BFH) and Cirrhosis of liver (CL) were separated 6 group, and ALT, TBA were determined by LDH-UV and BNT methods. Results The re- sults showed that positive rate of ALT were 100%, 85.9%, 64.6%, 100%, 100%, 40.6% and TBA were l00%, 89.l%, 75.9%, 100%, 100% 100% respectively in AIH, AAH, CH, SH, BFH and CL group. The positive rate of determined ALT associate with TBA in AAH, CH and CL were 95.3%, 87.5% and 100%, re- spectively. Conclusion It suggested that determined ALT associate with TBA can enhance the positive rate of AAH, CH and CL.

关 键 词：丙氨酸 氨基转移酶 总胆汁酸 肝炎 肝硬变 诊断 

分 类 号：R575.204[医药卫生—消化系统] R512.604[医药卫生—内科学]